Clifford Tabin

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Cliff Tabin
Professor Clifford Tabin ForMemRS.jpg
Cliff Tabin in 2014, portrait via the Royal Society
Born Clifford James Tabin
(1954-01-19) January 19, 1954 (age 70)[1]
Glencoe, Illinois
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Thesis Activation of the c-Ha-ras Oncogene (1984)
Doctoral advisor Robert Weinberg
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Known for Sonic hedgehog[23]
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Website
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Professor Clifford James Tabin (born 1954) is Chairman of the Department of Genetics at Harvard Medical School.[25][31][32]

Education

Tabin was educated at the University of Chicago where he was awarded a Bachelor of Science degree in Physics in 1976.[25] He went on to graduate school at Massachusetts Institute of Technology (MIT) and was awarded a PhD in 1984 for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by Robert Weinberg based in the MIT Department of Biology.[33] In Weinberg's lab Tabin constructed murine leukemia virus,[24] the first recombinant retrovirus that could be used as a eukaryotic vector.[31]

Career

Following his PhD, Tabin did postdoctoral research with Douglas A. Melton at Harvard University, then moved to Massachusetts General Hospital where he worked on the molecular biology of limb development. He was appointed to the faculty in the Department of Genetics at Harvard Medical School in 1989, and promoted to Full Professor in 1997 and Chairman of the Department in January 2007.[34][35]

Research

As of 2014 Tabin's research[36][37][38] investigates the genetic regulation of vertebrate development,[39][40][41] combining classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene expression during embryogenesis.[42][43][44]

Previously Tabin has worked on retroviruses, homeobox genes, oncogenes, developmental biology and evolution. Early in his research he investigated limb regeneration in the salamander, and described the expression of retinoic acid receptor and Hox genes in the blastema. Comparative studies by Ann Burke[45][46] in his lab showed that differences in boundaries of Hox gene expression correlated with differences in skeletal morphology.[2][47][48][49] The Tabin laboratory adjoins the laboratory of Connie Cepko.[50]

Awards and honours

Tabin was elected a Foreign Member of the Royal Society (ForMemRS) in 2014. His nomination reads: <templatestyles src="Template:Blockquote/styles.css" />

Tabin has made fundamental discoveries on embryonic development and evolution. A critical turning point in the history of developmental biology was the identification of the first known secreted morphogen, Sonic hedgehog. He clarified how morphogens like Shh orchestrate formation of the embryo, elucidating why the heart is located on the left and not the right side of the body and explaining why the thumb is different from the little finger. This provided critical insight into the origins of human congenital malformations. He has also solved important evolutionary riddles including the causes of variations in beak shape in Darwin's finches.[27]

Tabin has also been awarded the Edwin Conklin Medal in 2012,[28] the March of Dimes Prize in Developmental Biology jointly with Philip A. Beachy in 2008[29] and the NAS Award in Molecular Biology in 1999. He was elected a member of the National Academy of Sciences in 2007[30] and the American Academy of Arts and Sciences in 2000.

Personal life

Tabin is the son of Julius Tabin,[25][31][51] a nuclear physicist who worked with Enrico Fermi on the Manhattan Project in Los Alamos National Laboratory in New Mexico during World War II. His has a brother, Geoff Tabin, and two children. Tabin appears as himself in a BBC Horizon programme titled Hopeful Monsters.[52]

References

  1. ↑ Cliff Tabin, Harvard Medical School
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Tabin lab graduate student alumni, Harvard University
  23. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ 24.0 24.1 Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ 25.0 25.1 25.2 25.3 Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  27. ↑ 27.0 27.1 Lua error in package.lua at line 80: module 'strict' not found.
  28. ↑ 28.0 28.1 Clifford Tabin Awarded Conklin Medal, Society for Developmental Biology
  29. ↑ 29.0 29.1 Lua error in package.lua at line 80: module 'strict' not found.
  30. ↑ 30.0 30.1 Clifford J. Tabin, Harvard University, National Academy of Sciences
  31. ↑ 31.0 31.1 31.2 Lua error in package.lua at line 80: module 'strict' not found.
  32. ↑ CSHL Keynote: Dr. Clifford Tabin, Harvard Medical School on YouTube, Cold Spring Harbor Laboratory
  33. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  34. ↑ Cliff Tabin molbio seminar, Princeton University
  35. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  36. ↑ Clifford Tabin's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  37. ↑ List of publications from Microsoft Academic Search
  38. ↑ Clifford Tabin publications, Google Scholar
  39. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  40. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  41. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  47. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  48. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  49. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  50. ↑ Profile of Constance L. Cepko, Ph.D, BioTechniques Vol. 36, No. 5, 2004-05-05, p. 737
  51. ↑ Julius Tabin Obituary (1919-2012) Physicist helped develop atom bomb, Chicago Tribune, 2012-09-02
  52. ↑ Clifford Tabin at the Internet Movie Database
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