Coumestan

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Coumestan
Coumestan.png
Names
IUPAC name
[1]Benzoxolo[3,2-c]chromen-6-one
Identifiers
479-12-9 YesY
ChEBI CHEBI:72578 N
ChemSpider 553855 YesY
Jmol 3D model Interactive image
Interactive image
PubChem 638309
  • InChI=1S/C15H8O3/c16-15-13-9-5-1-3-7-11(9)17-14(13)10-6-2-4-8-12(10)18-15/h1-8H YesY
    Key: JBIZUYWOIKFETJ-UHFFFAOYSA-N YesY
  • InChI=1/C15H8O3/c16-15-13-9-5-1-3-7-11(9)17-14(13)10-6-2-4-8-12(10)18-15/h1-8H
    Key: JBIZUYWOIKFETJ-UHFFFAOYAF
  • C1=CC=C2C(=C1)C3=C(O2)C4=CC=CC=C4OC3=O
  • O=C3Oc4ccccc4c2oc1c(cccc1)c23
Properties
C15H8O3
Molar mass 236.22 g/mol
Melting point 187 to 188 °C (369 to 370 °F; 460 to 461 K)[1]
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Coumestan is a heterocyclic organic compound. Coumestan forms the central core of a variety of natural compounds known collectively as coumestans. Coumestans are oxidation products of pterocarpan[2] that are similar to coumarin. Coumestans, including coumestrol, a phytoestrogen, are found in a variety of plants. Food sources high in coumestans include split peas, pinto beans, lima beans, and especially alfalfa and clover sprouts.[3]

Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity than 17α-estradiol, although the estrogenic potency of coumestrol at both receptors is much less than that of 17β-estradiol.[4]

Because of the estrogenic activity of some coumestans, a variety of syntheses have been developed that allow the preparation of coumestans so that their pharmacological effects can be explored.[5][6]

Coumestans

References

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