Cyclin-dependent kinase 7

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Interactions

Cyclin-dependent kinase 7 has been shown to interact with:

• Androgen receptor,
• Cyclin H,
• GTF2H1,
• MNAT1,
• P53,
• SUPT5H, and
• XPB.

See also

• Cyclin-dependent kinase
• CDK7 pathway

External links

• CDK7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CDK7 human gene location in the UCSC Genome Browser.
• CDK7 human gene details in the UCSC Genome Browser.