Cyrus Chothia

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Cyrus Chothia
File:Alex Bateman Cyrus Chothia ISMB 2015.jpg
Cyrus Chothia (right), pictured with Alex Bateman at the ISMB conference in 2015.
Born Cyrus Homi Chothia
(1942-02-19) February 19, 1942 (age 82)[1]
Institutions <templatestyles src="Plainlist/styles.css"/>
Alma mater <templatestyles src="Plainlist/styles.css"/>
Thesis The crystal structures of some molecules active at cholinergic nerve receptors[4] (1973)
Doctoral advisor Peter J. Pauling[5]
Other academic advisors Michael Levitt[6]
Frederic M. Richards[6]
Doctoral students <templatestyles src="Plainlist/styles.css"/>
Other notable students Arthur Lesk (postdoc)
Notable awards <templatestyles src="Plainlist/styles.css"/>
Website
www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/cyrus-chothia

Cyrus Homi Chothia (b. 19 Feb. 1942)[1] FRS is an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB)[52][53] and emeritus fellow of Wolfson College, Cambridge.[49][54][55][56][57][58][59]

Education

Chothia was educated at Alleyn's School,[3] then went to study at Durham University graduating with a Bachelor of Science degree in 1965.[1] Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a PhD from University College London[4] under the supervision of Peter Pauling,[60] the son of Linus Pauling.

Research

After his Ph.D. Chothia worked in the Laboratory of Molecular Biology (LMB) for three years. He then worked with Michael Levitt[6] at the Weizmann Institute of Science [61][62] followed by two years with Joel Janin at the Institut Pasteur in Paris.[63]

In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk[2][64] he showed that proteins adapt to mutations by changes in structure.

In 1992 he proposed that most proteins are built of domains that come from a small number of families.[65] He collaborated with Alexey Murzin, Steven Brenner and Tim Hubbard to create the Structural Classification of Proteins (SCOP) database,[66][67] a periodic table for all known protein structures. With Julian Gough[32] he created the SUPERFAMILY database[68] which uses Hidden Markov models to identify protein sequences that are related to those of known structures.

During his career, Chothia supervised 19 PhD students[11] including Alex Bateman,[17] Steven E. Brenner,[23] Mark Bender Gerstein,[29] Julian Gough[31] and Sarah Teichmann.[44]

Awards and honours

Chothia was elected a Fellow of the Royal Society in 2000.[1] His certificate of election and candidature reads: <templatestyles src="Template:Blockquote/styles.css" />

Dr Chothia has shown how the amino sequences of proteins determine their structure, function and evolution. From an analysis of their structural regularities, he has developed a classification of protein structures that is now in general use. His picture of protein evolution suggests how proteins diverge and gain new functions. He has helped us to understand how their apparently limited set of slightly different structures allow immunoglobin to recognise an almost limitless variety of different antigens.[69]

In 2015, Chothia was elected a Fellow of the International Society for Computational Biology (ISCB)[70] and was selected to receive the ISCB Accomplishment by a Senior Scientist Award in honour of his work in using computational methods to understand protein structure.[50][71]

Alongside David Haussler and Michael Waterman, Chothia was awarded the 2015 Dan David Prize for his contributions to the field of bioinformatics.[51]

References

  1. ↑ 1.0 1.1 1.2 1.3 Lua error in package.lua at line 80: module 'strict' not found. (subscription required)
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Cyrus Chothia at the Mathematics Genealogy Project
  6. ↑ 6.0 6.1 6.2 Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ 11.0 11.1 Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  14. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  15. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ 17.0 17.1 Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  19. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  23. ↑ 23.0 23.1 Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  27. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  28. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  29. ↑ 29.0 29.1 Lua error in package.lua at line 80: module 'strict' not found.
  30. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  31. ↑ 31.0 31.1 Lua error in package.lua at line 80: module 'strict' not found.
  32. ↑ 32.0 32.1 Lua error in package.lua at line 80: module 'strict' not found.
  33. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  34. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  35. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  36. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  37. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  38. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  39. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  40. ↑ Cyrus Chothia's publications indexed by Google Scholar, a service provided by Google
  41. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  42. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  43. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  44. ↑ 44.0 44.1 Lua error in package.lua at line 80: module 'strict' not found.
  45. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  46. ↑ Lua error in package.lua at line 80: module 'strict' not found. open access publication - free to read
  47. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  48. ↑ Lua error in package.lua at line 80: module 'strict' not found. open access publication - free to read
  49. ↑ 49.0 49.1 Lua error in package.lua at line 80: module 'strict' not found.
  50. ↑ 50.0 50.1 Lua error in package.lua at line 80: module 'strict' not found.
  51. ↑ 51.0 51.1 Lua error in package.lua at line 80: module 'strict' not found.
  52. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  53. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  54. ↑ Cyrus Chothia's publications indexed by the DBLP Bibliography Server at the University of Trier
  55. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  56. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  57. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  58. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  59. ↑ Cyrus Chothia's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  60. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  61. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  62. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  63. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  64. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  65. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  66. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  67. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  68. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  69. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  70. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  71. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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