Dotarizine

Dotarizine

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Systematic (IUPAC) name
1-[diphenylmethyl]-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Identifiers
CAS Number	84625-59-2 Y
ATC code	none
PubChem	CID: 55285
ChemSpider	49929 N
UNII	IO7663S6D3 N
ChEMBL	CHEMBL2106316
Synonyms	Dotarizine
Chemical data
Formula	C29H34N2O2
Molecular mass	442.592 g/mol
SMILES C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5
InChI InChI=1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30(20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,10,17-24H2 N Key:LRMJAFKKJLRDLE-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT_2A receptor, and to a lesser extent at the 5HT_1A and 5HT_2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.