Epidemiological method

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The science of epidemiology has matured significantly from the times of Hippocrates and John Snow. The techniques for gathering and analyzing epidemiological data vary depending on the type of disease being monitored but each study will have overarching similarities.[1]

Outline of the process of an epidemiological study

  1. Establish that a problem exists
    • Full epidemiological studies are expensive and laborious undertakings. Before any study is started, a case must be made for the importance of the research.
  2. Confirm the homogeneity of the events
    • Any conclusions drawn from inhomogeneous cases will be suspicious. All events or occurrences of the disease must be true cases of the disease.
  3. Collect all the events
    • It is important to collect as much information as possible about each event in order to inspect a large number of possible risk factors. The events may be collected from varied methods of epidemiological study or from censuses or hospital records.
    • The events can be characterized by Incidence rates and prevalence rates.
    • Often, occurrence of a single disease entity is set as an event.
    • Given inherent heterogeneous nature of any given disease (i.e., the unique disease principle [2]), a single disease entity may be treated as disease subtypes.[3][4] This framework is well conceptualized in the interdisciplinary field of molecular pathological epidemiology (MPE).[5][6]
  4. Characterize the events as to epidemiological factors
    1. Predisposing factors
      • Non-environmental factors that increase the likelihood of getting a disease. Genetic history, age, and gender are examples.
    2. Enabling/disabling factors
      • Factors relating to the environment that either increase or decrease the likelihood of disease. Exercise and good diet are examples of disabling factors. A weakened immune system and poor nutrition are examples of enabling factors.
    3. Precipitation factors
      • This factor is the most important in that it identifies the source of exposure. It may be a germ, toxin or gene.
    4. Reinforcing factors
      • These are factors that compound the likelihood of getting a disease. They may include repeated exposure or excessive environmental stresses.
  5. Look for patterns and trends
    • Here one looks for similarities in the cases which may identify major risk factors for contracting the disease. Epidemic curves may be used to identify such risk factors.
  6. Formulate a hypothesis
    • If a trend has been observed in the cases, the researcher may postulate as to the nature of the relationship between the potential disease-causing agent and the disease.
  7. Test the hypothesis
    • Because epidemiological studies can rarely be conducted in a laboratory the results are often polluted by uncontrollable variations in the cases. This often makes the results difficult to interpret. Two methods have evolved to assess the strength of the relationship between the disease causing agent and the disease.
    • Koch's postulates were the first criteria developed for epidemiological relationships. Because they only work well for highly contagious bacteria and toxins, this method is largely out of favor.
    • Bradford-Hill Criteria are the current standards for epidemiological relationships. A relationship may fill all, some, or none of the criteria and still be true.
  8. Publish the results[7]

Measures

Epidemiologists are famous for their use of rates. Each measure serves to characterize the disease giving valuable information about contagiousness, incubation period, duration, and mortality of the disease.

Measures of occurrence

  1. Incidence measures
    1. Incidence rate, where cases included are defined using a case definition
    2. Hazard rate
    3. Cumulative incidence
  2. Prevalence measures
    1. Point prevalence
    2. Period prevalence

Measures of association

  1. Relative measures
    1. Risk ratio
    2. Rate ratio
    3. Odds ratio
    4. Hazard ratio
  2. Absolute measures
    1. Absolute risk reduction
    2. Attributable risk
      1. Attributable risk in exposed
      2. Percent attributable risk
      3. Levin’s attributable risk

Other measures

  1. Virulence and Infectivity
  2. Mortality rate and Morbidity rate
  3. Case fatality
  4. Sensitivity (tests) and Specificity (tests)

Criticism

Epidemiological studies show association not causation.[8]

See also

External links

References

  1. ↑ Miquel Porta (2014) A dictionary of epidemiology, 6th edn, New York: Oxford University Press. ISBN 9780199976737.
  2. ↑ Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt AJ, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol 2013;26:465-484.
  3. ↑ Begg CB. A strategy for distinguishing optimal cancer subtypes. Int J Cancer 2011; 129: 931-937.
  4. ↑ Begg CB, Zabor EC. Detecting and Exploiting Etiologic Heterogeneity in Epidemiologic Studies. Am J Epidemiol 2012; 176: 512-518.
  5. ↑ Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst 2010;102:365-367.
  6. ↑ Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2011;60:397-411
  7. ↑ Austin, Donald F., and S. B. Werner. Epidemiology for the health sciences a primer on epidemiological concepts and their uses. Springfield, Ill: C. C. Thomas, 1974. Print.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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