Etazolate

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Etazolate
Etazolate.svg
Systematic (IUPAC) name
Ethyl 1-ethyl-4-[2-(propan-2-ylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
Clinical data
Legal status
  • Uncontrolled
Routes of
administration		 Oral
Identifiers
CAS Number 51022-77-6
ATC code none
PubChem CID: 3277
IUPHAR/BPS 7336
ChemSpider 3162
UNII I89Y79062L YesY
ChEMBL CHEMBL356388
Chemical data
Formula C14H19N5O2
Molecular mass 289.33 g/mol
  • CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC

Etazolate (SQ-20,009, EHT-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties.[1][2][3] It acts as a positive allosteric modulator of the GABAA receptor at the barbiturate binding site,[4][5][6][7] as an adenosine antagonist of the A1 and A2 subtypes,[8] and as a phosphodiesterase inhibitor selective for the PDE4 isoform.[9][10][11] It is currently in clinical trials for the treatment of Alzheimer's disease.[12]

Synthesis

Cartazolate and Etazolate synthesis: E.R. SQUIBB & SONS, INC., NEW YORK, N.Y., US. DE 2123318 

See also

References

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