FYN

FYN proto-oncogene, Src family tyrosine kinase
250px PDB rendering based on 1a0n.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK
Identifiers
Symbols	FYN ; SLK; SYN; p59-FYN
External IDs	OMIM: 137025 MGI: 95602 HomoloGene: 48068 ChEMBL: 1841 GeneCards: FYN Gene
EC number	2.7.10.2
Gene ontology Molecular function • G-protein coupled receptor binding • glycoprotein binding • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • tubulin binding • T cell receptor binding • CD4 receptor binding • CD8 receptor binding • phosphatidylinositol 3-kinase binding • ion channel binding • metal ion binding • ephrin receptor binding • peptide hormone receptor binding • growth factor receptor binding Cellular component • nucleus • mitochondrion • endosome • cytosol • actin filament • plasma membrane • postsynaptic density • extrinsic component of cytoplasmic side of plasma membrane • membrane raft Biological process • neuron migration • stimulatory C-type lectin receptor signaling pathway • adaptive immune response • protein phosphorylation • calcium ion transport • transmembrane receptor protein tyrosine kinase signaling pathway • epidermal growth factor receptor signaling pathway • axon guidance • blood coagulation • learning • feeding behavior • regulation of cell shape • fibroblast growth factor receptor signaling pathway • negative regulation of gene expression • positive regulation of neuron projection development • positive regulation of phosphatidylinositol 3-kinase signaling • viral process • cell migration • peptidyl-tyrosine phosphorylation • cell differentiation • platelet activation • forebrain development • T cell costimulation • negative regulation of protein ubiquitination • intracellular signal transduction • cellular response to platelet-derived growth factor stimulus • peptidyl-tyrosine autophosphorylation • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • T cell activation • regulation of cell proliferation • negative regulation of protein catabolic process • response to drug • positive regulation of tyrosine phosphorylation of Stat5 protein • regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of neuron apoptotic process • innate immune response • response to ethanol • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • phosphatidylinositol-mediated signaling • dendrite morphogenesis • regulation of defense response to virus by virus • activated T cell proliferation • T cell receptor signaling pathway • leukocyte migration • detection of mechanical stimulus involved in sensory perception of pain • cellular response to peptide hormone stimulus • cellular response to transforming growth factor beta stimulus • positive regulation of protein localization to nucleus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FYN 210105 s at tn.png
File:PBB GE FYN 212486 s at tn.png
File:PBB GE FYN 216033 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2534	14360
Ensembl	ENSG00000010810	ENSMUSG00000019843
UniProt	P06241	P39688
RefSeq (mRNA)	NM_001242779	NM_001122892
RefSeq (protein)	NP_002028	NP_001116364
Location (UCSC)	Chr 6: 111.66 – 111.87 Mb	Chr 10: 39.37 – 39.57 Mb
PubMed search	[1]	[2]

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

Function

Fyn is a protein, present in the signaling pathway of integrins, which activates ras. Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of tyrosine protein kinases. Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane, where it phosphorylates tyrosine residues on key targets involved in a variety of different signaling pathways. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules.

Role in signaling pathways

At least three tools have been useful in discerning a requirement for Fyn function in a particular signaling system:

• cells derived from Fyn-/- mice (as well as cells derived from Fyn, Src, Yes, Fyn triple knockout mice (SYF));
• a kinase-inactive, dominant negative mutant form of Fyn (K299M);
• pharmacologic inhibitors of Src family kinases, such as PP2; note that PP2 also inhibits other tyrosine protein kinases such as Abl, PDGFR and c-Kit.

Using these tools, a requirement for Fyn has been shown for the following signaling pathways: T and B cell receptor signaling, integrin-mediated signaling, growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation of natural killer cells, oligodendrocytes and keratinocytes.

Additionally, Fyn has been shown to be important for both protective immunity and the onset of autoimmunity.

Interactions

FYN has been shown to interact with:

• ADD2,
• BCAR1,
• C-Raf,
• CBLC,
• CD36,
• CD44,
• CDH1,
• CHRNA7,
• CTNND1,
• CBL,
• CSF1R,
• DLG4,
• Dystroglycan,
• EPHA8,
• FYB,
• FASLG,
• GNB2L1,
• GRIN2A,
• ITK,
• Janus kinase 2,
• KHDRBS1,
• LCK,
• LKB1,
• Nephrin,
• PAG1,
• PIK3R2,
• PRKCQ,
• PTK2B,
• PTK2,
• PTPRT)
• UNC119,
• RICS,
• SH2D1A,
• SKAP1,
• Syk,
• TNK2,
• TRPC6,
• Tau protein,
• TrkB,
• TYK2,
• TUBA3C,
• WAS, and
• ZAP-70,