Fabomotizole
Systematic (IUPAC) name | |
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5-Ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole
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Clinical data | |
Trade names | Afobazole |
Legal status |
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Routes of administration |
Oral |
Pharmacokinetic data | |
Bioavailability | 43.64%, pronounced first-pass effect |
Metabolism | extensive hepatic |
Onset of action | 0.85±0.13 hours |
Biological half-life | 0.82±0,54 hours |
Identifiers | |
CAS Number | 173352-39-1 |
ATC code | N05BX04 (WHO) |
PubChem | CID: 9862937 |
ChemSpider | 8038633 |
UNII | HDO6HX6NZU |
Synonyms | Fabomotizole |
Chemical data | |
Formula | C15H21N3O2S |
Molecular mass | 307.410 g/mol |
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Fabomotizole (INN)[1] (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors.[2][3][4][5][6] Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety.[7]
Experiments of mice have shown antimutagenic and antiteratogenic properties.[8]
Fabomotizole has found little clinical use outside Russia and has not been evaluated by the FDA.
References
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- Drugs with non-standard legal status
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Anxiolytics
- Drugs with unknown mechanisms of action
- Morpholines
- Thioethers
- Benzimidazoles
- Phenol ethers
- Russian drugs
- Melatonin receptor antagonists
- Monoamine oxidase inhibitors
- Sigma agonists
- Nervous system drug stubs