File:Anaplastic astrocytoma - gfap - very high mag.jpg
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Summary
Very high magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of an <a href="https://en.wikipedia.org/wiki/anaplastic_astrocytoma" class="extiw" title="w:anaplastic astrocytoma">anaplastic astrocytoma</a>. <a href="https://en.wikipedia.org/wiki/GFAP" class="extiw" title="w:GFAP">GFAP immunostain</a>.
The typical features are present:
- Marked nuclear atypia.
- Elongated nuclei (consistent with derivation from an astrocyte ).
- Mitoses.
- Fine fibrillary processes (consistent with a glial cell population).
- Cytoplasmic staining of atypical cells with GFAP.
- p53 immunohistochemical stain positivity.
- High proliferative rate based on Ki-67 staining.
Related images
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_low_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/120px-Anaplastic_astrocytoma_-_low_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/180px-Anaplastic_astrocytoma_-_low_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/240px-Anaplastic_astrocytoma_-_low_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
Low mag.
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/120px-Anaplastic_astrocytoma_-_intermed_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/180px-Anaplastic_astrocytoma_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/240px-Anaplastic_astrocytoma_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
Intermed. mag.
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
High mag.
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
Very high mag.
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
Ki-67. High mag.
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<a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a>
p53. Very high mag.
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File history
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 10:28, 12 January 2017 | 4,272 × 2,848 (7.31 MB) | 127.0.0.1 (talk) | Very high magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of an <b><a href="https://en.wikipedia.org/wiki/anaplastic_astrocytoma" class="extiw" title="w:anaplastic astrocytoma">anaplastic astrocytoma</a></b>. <a href="https://en.wikipedia.org/wiki/GFAP" class="extiw" title="w:GFAP">GFAP immunostain</a>. <p>The typical features are present: </p> <ul> <li>Marked nuclear atypia.</li> <li>Elongated nuclei (consistent with derivation from an astrocyte ).</li> <li>Mitoses.</li> <li>Fine fibrillary processes (consistent with a glial cell population).</li> <li>Cytoplasmic staining of atypical cells with GFAP.</li> <li>p53 immunohistochemical stain positivity.</li> <li>High proliferative rate based on Ki-67 staining.</li> </ul> <h2><span class="mw-headline" id="Related_images">Related images</span></h2> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_low_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/120px-Anaplastic_astrocytoma_-_low_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/180px-Anaplastic_astrocytoma_-_low_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/240px-Anaplastic_astrocytoma_-_low_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Low mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/120px-Anaplastic_astrocytoma_-_intermed_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/180px-Anaplastic_astrocytoma_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/240px-Anaplastic_astrocytoma_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>High mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Very high mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Ki-67. High mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>p53. Very high mag. </p> </div> </div></li> </ul> | |
10:28, 12 January 2017 | 4,272 × 2,848 (7.31 MB) | 127.0.0.1 (talk) | Very high magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of an <b><a href="https://en.wikipedia.org/wiki/anaplastic_astrocytoma" class="extiw" title="w:anaplastic astrocytoma">anaplastic astrocytoma</a></b>. <a href="https://en.wikipedia.org/wiki/GFAP" class="extiw" title="w:GFAP">GFAP immunostain</a>. <p>The typical features are present: </p> <ul> <li>Marked nuclear atypia.</li> <li>Elongated nuclei (consistent with derivation from an astrocyte ).</li> <li>Mitoses.</li> <li>Fine fibrillary processes (consistent with a glial cell population).</li> <li>Cytoplasmic staining of atypical cells with GFAP.</li> <li>p53 immunohistochemical stain positivity.</li> <li>High proliferative rate based on Ki-67 staining.</li> </ul> <h2><span class="mw-headline" id="Related_images">Related images</span></h2> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_low_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/120px-Anaplastic_astrocytoma_-_low_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/180px-Anaplastic_astrocytoma_-_low_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/3/37/Anaplastic_astrocytoma_-_low_mag.jpg/240px-Anaplastic_astrocytoma_-_low_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Low mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/120px-Anaplastic_astrocytoma_-_intermed_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/180px-Anaplastic_astrocytoma_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Anaplastic_astrocytoma_-_intermed_mag.jpg/240px-Anaplastic_astrocytoma_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/4/46/Anaplastic_astrocytoma_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>High mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Anaplastic_astrocytoma_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Very high mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/120px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/180px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg/240px-Anaplastic_astrocytoma_-_ki67_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Ki-67. High mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/120px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/180px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/8/82/Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg/240px-Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>p53. Very high mag. </p> </div> </div></li> </ul> |
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