File:CAPON Binds Nitric Oxide Synthase, Regulating NMDA Receptor–Mediated Glutamate Neurotransmission.png
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Summary
Binding of CAPON results in a reduction of NMDA receptor/nitric oxide synthase (NOS) complexes, leading to decreased NMDA receptor–gated calcium influx and a catalytically inactive nitric oxide synthase. Overexpression of either the full-length or the novel shortened CAPON isoform as reported by Brzustowicz and colleagues is, therefore, predicted to lead to impaired NMDA receptor–mediated glutamate neurotransmission.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:12, 6 January 2017 | | 1,370 × 956 (493 KB) | 127.0.0.1 (talk) | Binding of CAPON results in a reduction of NMDA receptor/nitric oxide synthase (NOS) complexes, leading to decreased NMDA receptor–gated calcium influx and a catalytically inactive nitric oxide synthase. Overexpression of either the full-length or the novel shortened CAPON isoform as reported by Brzustowicz and colleagues is, therefore, predicted to lead to impaired NMDA receptor–mediated glutamate neurotransmission. |
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