File:MiRNA-biogenesis.jpg
Summary
Overview of <a href="https://en.wikipedia.org/wiki/microRNA" class="extiw" title="en:microRNA">microRNA</a> processing in animals, from <a href="https://en.wikipedia.org/wiki/transcription_(genetics)" class="extiw" title="en:transcription (genetics)">transcription</a> to the formation of the effector complex. There are two pathways, one for microRNAs from independent genes and one for <a href="https://en.wikipedia.org/wiki/intron" class="extiw" title="en:intron">intronic</a> microRNAs.
Enzymes in the picture:
<a href="https://en.wikipedia.org/wiki/Drosha" class="extiw" title="en:Drosha">Drosha</a>, <a href="https://en.wikipedia.org/wiki/Pasha_(protein)" class="extiw" title="en:Pasha (protein)">Pasha</a> (pri-miRNA → pre-miRNA)
<a href="https://en.wikipedia.org/wiki/Spliceosome" class="extiw" title="en:Spliceosome">Spliceosome</a> (pre-mRNA → intron lariat)
<a href="https://en.wikipedia.org/wiki/DBR1" class="extiw" title="en:DBR1">Debranching enzyme</a> (intron lariat → RNA that can fold into pre-miRNA)
<a href="https://en.wikipedia.org/wiki/Ran_(biology)" class="extiw" title="en:Ran (biology)">RAN-GTP</a>, <a href="https://en.wikipedia.org/wiki/XPO5" class="extiw" title="en:XPO5">Exportin-5</a> (export from nucleus)
<a href="https://en.wikipedia.org/wiki/Dicer" class="extiw" title="en:Dicer">Dicer</a> (pre-miRNA → miRNA)
Abbrevations:
pri-miRNA = primary microRNA transcript
pre-mRNA = precursor messenger RNA
pre-miRNA = precursor microRNA
miRNA = microRNA
miRNA* = antisense microRNA
miRNP = microRNA ribonucleoprotein
Licensing
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File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 22:51, 13 January 2017 | | 1,520 × 1,610 (348 KB) | 127.0.0.1 (talk) | Overview of <a href="https://en.wikipedia.org/wiki/microRNA" class="extiw" title="en:microRNA">microRNA</a> processing in animals, from <a href="https://en.wikipedia.org/wiki/transcription_(genetics)" class="extiw" title="en:transcription (genetics)">transcription</a> to the formation of the effector complex. There are two pathways, one for microRNAs from independent genes and one for <a href="https://en.wikipedia.org/wiki/intron" class="extiw" title="en:intron">intronic</a> microRNAs. <p><b>Enzymes in the picture:</b><br><a href="https://en.wikipedia.org/wiki/Drosha" class="extiw" title="en:Drosha">Drosha</a>, <a href="https://en.wikipedia.org/wiki/Pasha_(protein)" class="extiw" title="en:Pasha (protein)">Pasha</a> (pri-miRNA → pre-miRNA)<br><a href="https://en.wikipedia.org/wiki/Spliceosome" class="extiw" title="en:Spliceosome">Spliceosome</a> (pre-mRNA → intron lariat)<br><a href="https://en.wikipedia.org/wiki/DBR1" class="extiw" title="en:DBR1">Debranching enzyme</a> (intron lariat → RNA that can fold into pre-miRNA)<br><a href="https://en.wikipedia.org/wiki/Ran_(biology)" class="extiw" title="en:Ran (biology)">RAN-GTP</a>, <a href="https://en.wikipedia.org/wiki/XPO5" class="extiw" title="en:XPO5">Exportin-5</a> (export from nucleus)<br><a href="https://en.wikipedia.org/wiki/Dicer" class="extiw" title="en:Dicer">Dicer</a> (pre-miRNA → miRNA) </p> <b>Abbrevations:</b> <br>pri-miRNA = primary microRNA transcript<br>pre-mRNA = precursor messenger RNA<br>pre-miRNA = precursor microRNA <br>miRNA = microRNA <br>miRNA* = antisense microRNA <br>miRNP = microRNA ribonucleoprotein |
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