File:Vasculitic neuropathy - plastics - low mag.jpg

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Summary

Low magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of a vasculitic neuropathy, also <a href="https://en.wikipedia.org/wiki/neuropathy" class="extiw" title="w:neuropathy">neuropathy</a> due to a <a href="https://en.wikipedia.org/wiki/vasculitis" class="extiw" title="w:vasculitis">vasculitis</a>. Resin section (plastics) with <a href="https://en.wikipedia.org/wiki/toluidine_blue_stain" class="extiw" title="w:toluidine blue stain">toluidine blue stain</a>.

The pathologic features of vasculitic neuropathy are evident:

  • Zonal involvement of the nerve fascicles with:
    • Loss of myelin.
    • Wallerian degeneration.
    • Regeneration.

Chronic active vasculitis:

The vasculitis in this case affects both small (< 100 micrometers) and medium vessels. <a href="https://en.wikipedia.org/wiki/granuloma" class="extiw" title="w:granuloma">Granulomas</a> are absent. Eosinophils are rare. Histomorphologic, diagnostic considerations are <a href="https://en.wikipedia.org/wiki/polyarteritis_nodosa" class="extiw" title="w:polyarteritis nodosa">polyarteritis nodosa</a> and <a href="https://en.wikipedia.org/wiki/microscopic_polyangiitis" class="extiw" title="w:microscopic polyangiitis">microscopic polyangiitis</a>.

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Licensing

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File history

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Date/TimeThumbnailDimensionsUserComment
current08:40, 16 January 2017Thumbnail for version as of 08:40, 16 January 20174,272 × 2,848 (3.3 MB)127.0.0.1 (talk)Low magnification <a href="https://en.wikipedia.org/wiki/micrograph" class="extiw" title="w:micrograph">micrograph</a> of a <b>vasculitic neuropathy</b>, also <b><a href="https://en.wikipedia.org/wiki/neuropathy" class="extiw" title="w:neuropathy">neuropathy</a> due to a <a href="https://en.wikipedia.org/wiki/vasculitis" class="extiw" title="w:vasculitis">vasculitis</a></b>. Resin section (plastics) with <a href="https://en.wikipedia.org/wiki/toluidine_blue_stain" class="extiw" title="w:toluidine blue stain">toluidine blue stain</a>. <p>The pathologic features of vasculitic neuropathy are evident: </p> <ul><li>Zonal involvement of the nerve fascicles with: <ul> <li>Loss of myelin.</li> <li>Wallerian degeneration.</li> <li>Regeneration.</li> </ul> </li></ul> <p>Chronic active vasculitis: </p> <ul> <li>Active features: <ul> <li>Perivascular and mural inflammatory infiltrate including lymhocytes and histocytes.</li> <li>Plump (reactive) <a href="https://en.wikipedia.org/wiki/endothelium" class="extiw" title="w:endothelium">endothelial cells</a>.</li> <li>Vessel wall cell death (<a href="https://en.wikipedia.org/wiki/necrosis" class="extiw" title="w:necrosis">necrosis</a>).</li> </ul> </li> <li>Chronic features: <ul> <li>Vessel wall thicking due to <a href="https://en.wikipedia.org/wiki/hyperplasia" class="extiw" title="w:hyperplasia">hyperplasia</a>.</li> <li>Dense fibrous tissue around the vessel.</li> </ul> </li> </ul> <p>The vasculitis in this case affects both small (< 100 micrometers) and medium vessels. <a href="https://en.wikipedia.org/wiki/granuloma" class="extiw" title="w:granuloma">Granulomas</a> are absent. Eosinophils are rare. Histomorphologic, diagnostic considerations are <a href="https://en.wikipedia.org/wiki/polyarteritis_nodosa" class="extiw" title="w:polyarteritis nodosa">polyarteritis nodosa</a> and <a href="https://en.wikipedia.org/wiki/microscopic_polyangiitis" class="extiw" title="w:microscopic polyangiitis">microscopic polyangiitis</a>. </p> <h2><span class="mw-headline" id="Related_images">Related images</span></h2> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-_plastics_-_low_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Vasculitic_neuropathy_-_plastics_-_low_mag.jpg/120px-Vasculitic_neuropathy_-_plastics_-_low_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Vasculitic_neuropathy_-_plastics_-_low_mag.jpg/180px-Vasculitic_neuropathy_-_plastics_-_low_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/f/f6/Vasculitic_neuropathy_-_plastics_-_low_mag.jpg/240px-Vasculitic_neuropathy_-_plastics_-_low_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Low mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/7/76/Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg/120px-Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/7/76/Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg/180px-Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/7/76/Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg/240px-Vasculitic_neuropathy_-_plastics_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:15px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-_plastics_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Vasculitic_neuropathy_-_plastics_-_high_mag.jpg/80px-Vasculitic_neuropathy_-_plastics_-_high_mag.jpg" width="80" height="120" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Vasculitic_neuropathy_-_plastics_-_high_mag.jpg/120px-Vasculitic_neuropathy_-_plastics_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Vasculitic_neuropathy_-_plastics_-_high_mag.jpg/160px-Vasculitic_neuropathy_-_plastics_-_high_mag.jpg 2x" data-file-width="2848" data-file-height="4272"></a></div></div> <div class="gallerytext"> <p>High mag. </p> </div> </div></li> </ul> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg/120px-Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg/180px-Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg/240px-Vasculitic_neuropathy_-n-_plastics_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Intermed. mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg/120px-Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg/180px-Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg/240px-Vasculitic_neuropathy_-n-_plastics_-_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>High mag. </p> </div> </div></li> <li class="gallerybox" style="width: 155px"><div style="width: 155px"> <div class="thumb" style="width: 150px;"><div style="margin:35px auto;"><a href="//commons.wikimedia.org/wiki/File:Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg" class="image"><img alt="" src="https://upload.wikimedia.org/wikipedia/commons/thumb/5/50/Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg/120px-Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg" width="120" height="80" srcset="https://upload.wikimedia.org/wikipedia/commons/thumb/5/50/Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg/180px-Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg 1.5x, https://upload.wikimedia.org/wikipedia/commons/thumb/5/50/Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg/240px-Vasculitic_neuropathy_-n-_plastics_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848"></a></div></div> <div class="gallerytext"> <p>Very high mag. </p> </div> </div></li> </ul>
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