Fluorometholone

Fluorometholone

Systematic (IUPAC) name
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682660
Pregnancy category	C
Identifiers
CAS Number	426-13-1 Y
ATC code	C05AA06 (WHO) D07AB06, D07XB04 (combinations), D10AA01, S01BA07
PubChem	CID: 9878
IUPHAR/BPS	7079
DrugBank	DB00324 Y
ChemSpider	9494 Y
UNII	SV0CSG527L Y
KEGG	D01367 Y
ChEBI	CHEBI:31625 N
ChEMBL	CHEMBL1200600 N
Synonyms	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical data
Formula	C22H29FO4
Molecular mass	376.462 g/mol
SMILES O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 Y Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N Y
NY (what is this?)  (verify)

Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon).

Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

See also

• Glucocorticoid
• Corticosteroid

External links

• Drugs.com
• flarex
• Alcon official page