Fluperlapine

Fluperlapine

Systematic (IUPAC) name
3-fluoro-6-(4-methylpiperazin-1-yl)-11H-dibenzo[b,e]azepine
Identifiers
CAS Number	67121-76-0 N
ATC code	none
PubChem	CID: 49381
ChemSpider	44882 Y
UNII	EWG253M961 Y
ChEMBL	CHEMBL63756 Y
Chemical data
Formula	C19H20FN3
Molecular mass	309.381 g/mol
SMILES Fc4ccc3c(/N=C(/N1CCN(C)CC1)c2ccccc2C3)c4
InChI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3 Y Key:OBWGMKKHCLHVIE-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Fluperlapine (NB 106-689), also known as fluoroperlapine, is a Morphanthridine atypical antipsychotic with additional antidepressant and sedative effects. It was first synthesized in 1979, and then subsequently studied in animals and humans in 1984 and beyond, but despite demonstrating efficacy in the treatment of a variety of medical conditions including schizophrenia, psychosis associated with Parkinson's disease, depressive symptoms, and dystonia, it was never marketed. This was perhaps due to its capacity for producing potentially life-threatening agranulocytosis, similarly to clozapine, which it closely resembles both structurally and pharmacologically.

Binding profile

Receptor	Ki (nM)
5-HT2A	7.9
5-HT2C	18.2
5-HT6	29
5-HT7	4.6
M1	8.8
M2	71
M3	41
M4	14
M5	17
D1	85
D2	316.2
D3	254.7
D4	21

See also

• Clozapine