GABRD

From Infogalactic: the planetary knowledge core
Jump to: navigation, search

<templatestyles src="Module:Infobox/styles.css"></templatestyles>

Gamma-aminobutyric acid (GABA) A receptor, delta
Identifiers
Symbols GABRD ; EIG10; EJM7; GEFSP5
External IDs OMIM137163 MGI95622 HomoloGene55489 IUPHAR: 416 ChEMBL: 3591 GeneCards: GABRD Gene
RNA expression pattern
PBB GE GABRD 208457 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2563 14403
Ensembl ENSG00000187730 ENSMUSG00000029054
UniProt O14764 P22933
RefSeq (mRNA) NM_000815 NM_008072
RefSeq (protein) NP_000806 NP_032098
Location (UCSC) Chr 1:
2.02 – 2.03 Mb
Chr 4:
155.38 – 155.4 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.[1][2][3]

Function

γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. The GABAA receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.[3]

Cell type-specific expression

In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells.[4] Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.[4]

See also

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
  4. 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


<templatestyles src="Asbox/styles.css"></templatestyles>