GRID1

Glutamate receptor, ionotropic, delta 1
Identifiers
Symbols	GRID1 ; GluD1
External IDs	OMIM: 610659 MGI: 95812 HomoloGene: 69017 IUPHAR: 448 ChEMBL: 2936 GeneCards: GRID1 Gene
Gene ontology Molecular function • ionotropic glutamate receptor activity • extracellular-glutamate-gated ion channel activity Cellular component • plasma membrane • ionotropic glutamate receptor complex • cell junction • dendrite • postsynaptic membrane • extracellular exosome Biological process • ion transmembrane transport • social behavior • ionotropic glutamate receptor signaling pathway • synaptic transmission, glutamatergic Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE GRID1 gnf1h05720 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2894	14803
Ensembl	ENSG00000182771	ENSMUSG00000041078
UniProt	Q9ULK0	Q61627
RefSeq (mRNA)	NM_017551	NM_008166
RefSeq (protein)	NP_060021	NP_032192
Location (UCSC)	Chr 10: 85.6 – 86.37 Mb	Chr 14: 34.82 – 35.58 Mb
PubMed search	[1]	[2]

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein that in humans is encoded by the GRID1 gene.

Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.

See also

• GRID2

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.