Ganglion cyst

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Not to be confused with Ganglion (nervous tissue structure).
Ganglion cyst
File:Ganglion-cyst.jpg
Cyst on dorsum of left hand close to the wrist
Classification and external resources
Specialty Plastic surgery
ICD-10 M67.4
ICD-9-CM 727.4
DiseasesDB 31229
eMedicine orthoped/493
Patient UK Ganglion cyst
MeSH D045888
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]

A ganglion cyst, or a synovial cyst, [1] also known as Gideon's Disease, a Bible Cyst, or a Bible Bump,[2] is a non-neoplastic soft tissue lump that may occur in any joint, but most often occurs on, around, or near joints and tendons in the hands or feet.[3] These cysts are caused by leakage of fluid from the joint into the surrounding tissue.[4]

Signs and symptoms

The average size of these cysts is 2.0 cm, but excised cysts of more than 5 cm have been reported.[5] The size of the cyst may vary over time, and may increase after activity.

Sites

These cysts most frequently occur around the dorsum of the wrist and on the fingers. A common site of occurrence is along the extensor carpi radialis brevis as it passes over the dorsum of the wrist joint. Although most commonly found in the wrist, ganglion cysts also may occur in the foot.[6]

Ganglion cysts are "commonly observed in association with the joints and tendons of the appendicular skeleton, with 88% 'in communication with the multiple small joints of the hand and wrist' and 11% with those of the foot and ankle." [5] Most often, they are found near the wrist joint, especially at the scapho-lunate area, which accounts for 80% of all ganglion cysts.[citation needed]

In a 2007 study of patients whose foot lumps were being removed surgically in Glasgow, 39 of 101 cases were ganglion cysts. The study replicated earlier findings that no ganglion cysts were found on the sole or heel of the foot; the authors wrote that "Although lumps in these areas may be ganglia, the surgeon should probably consider other diagnoses in the first instance." The researchers also noted a marked preponderance of occurrence among females (85%) and that 11 of the other cases had been misdiagnosed as ganglion cysts before surgery.[7]

Ganglion cysts are not limited to the hands and feet. They may occur near the knee, commonly near the cruciate ligaments, but also they may occur at the origins of the gastrocnemius tendon and anteriorly on Hoffa's infrapatellar fat pad.[8] At the shoulder, they typically occur at the acromioclavicular joint or along the biceps tendon.[9]

From their common origin at a joint or tendon, ganglion cysts may form in a wide range of locations. Rarely, intraosseous ganglion cysts occur, sometimes in combination with a cyst in the overlying soft tissue.[5][10] Very rare cases of intramuscular ganglion cysts in the gastrocnemius muscle of the calf have been reported.[11][12] It is possible for a cyst to be displaced considerably from its connection to the joint. In one extreme case, a ganglion cyst was observed to propagate extensively via the conduit of the common peroneal nerve sheath to a location in the thigh; in such cases surgery to the proximal joint to remove the articular connection may remove the need for a riskier, more extensive surgery in the neural tissue of the thigh.[13] The cysts may intrude into the spine, which may cause pain and dysesthesia in distant extremities.[14]

It has been proposed recently that cystic adventitial disease, in which a cyst occurs within the popliteal artery near the knee, may occur by an articular mechanism, with a conduit leading from the joint, similar to the development of ganglion cysts, that spread within the peroneal nerve.[15]

Cysts also have been reported to occur near the shoulder joint that were compressing one or more nerves and causing bone erosions.[16]

Cause

The most commonly accepted cause of ganglion cysts is the "herniation hypothesis", by which they are thought to occur as "an out-pouching or distention of a weakened portion of a joint capsule or tendon sheath." This description is based on the observations that the cysts occur close to tendons and joints, the microscopic anatomy of the cyst resembles that of the tenosynovial tissue, the fluid is similar in composition to synovial fluid, and dye injected into the joint capsule frequently ends up in the cyst, which may become enlarged after activity. Dye injected into the cyst rarely enters the joint, however, which has been attributed to the formation of an effective and one-way "check valve" allowing fluid out of the joint, but not back in.[5] Synovial cysts, posttraumatic degeneration of connective tissue, and inflammation have been considered as the causes. Other possible mechanisms for the development of ganglion cysts include repeated mechanical stress, facet arthrosis, myxoid degeneration of periarticular fibrous tissues and liquefaction with chronic damage, increased production of hyaluronic acid by fibroblasts, and a proliferation of mesenchymal cells. Ganglion cysts also may develop independently from a joint.[14][17]

Double bass players are known to develop ganglion cysts on their wrists as a result of extensive use of a German bow. [18]

Diagnosis

File:Ganglion Cyst, Hand.jpg
Ganglion cyst of the hand with multiple cystic chambers containing glairy material. The walls are composed of bland fibrous tissue with no specialized lining.

Ganglion cysts are diagnosed easily, as they are visible and pliable to touch.

Radiographs in AP and lateral views should be obtained to exclude any more serious underlying pathology.[19] Ultrasonography (US) may be used to increase diagnostic confidence in clinically suspected lesions or to depict occult cysts,[20] because intratendinous ganglia are readily distinguished from extratendinous ganglia during dynamic US, as microscopically, ganglionic cysts are thin-walled cysts containing clear, mucinous fluid.[6]

Treatment

Other than the frequent choice to leave the cyst in place, surgical treatments remain the primary elective option for treatment of ganglion cysts. The progression of ganglion surgery worldwide is to use an arthroscopic or mini-opening method.[21] Alternatively, a hypodermic needle may be used to drain the fluid from the cyst (via aspiration) and a corticosteroid may be injected after the cyst is empty,[20] however, if the fluid has thickened, owing to the passage of time, this treatment is not always effective.[citation needed] There is a recurrence rate of approximately 50% following needle drainage (aspiration) of ganglion cysts.

One common method of treatment for a ganglion cyst has been to strike the lump with a large heavy book, causing the cyst to rupture and drain into the surrounding tissues. Historically, a Bible was the largest or only book in any given household and commonly was used for this treatment. This led to the nickname of "Bible bumps" or "Gideon's disease" for these cysts.[2][22] This treatment is not now recommended.

Complications

Complications of treatment may include stiffness in the hand or location, and scar formation.[20] Recurrence of the lesion is more common following excision of a volar ganglion cyst in the wrist. Incomplete excision that fails to include the stalk or pedicle also may lead to recurrence, as will failing to execute a layered closure of the incision.[23]

Prognosis

Recurrence rate is higher in aspirated cysts than in excised ones.[19] Ganglion cysts have been found to recur following surgery in 12% [24] to 41% [25] of patients.

A six-year outcome study of the treatment of ganglion cysts on the dorsum (back) of the wrist compared excision, aspiration, and no treatment. Neither excision nor aspiration provided long-term benefit better than no treatment. Of the untreated ganglion cysts, 58% resolved spontaneously; the post-surgery recurrence rate in this study was 39%.[26] A similar study in 2003 of ganglion cysts occurring on the palmar surface of the wrist states: "At 2 and 5 year follow-up, regardless of treatment, no difference in symptoms was found, regardless of whether the palmar wrist ganglion was excised, aspirated or left alone."[27]

Additional images

Etymology

Being a misnomer that has persisted into modern times,[28] the ganglion cyst is unrelated to the neural "ganglion" or "ganglion cell"; its etymology traces back to the ancient Greek γάγγλιον, a "knot" or "swelling beneath the skin",[29] which extends to the neural masses by analogy. Generally, Hippocrates is credited with the description of these cysts.[5][30]

The term "Bible cyst" (or "Bible bump") is derived from a common treatment in the past that consisted of hitting the cyst with a Bible or a similarly large book.[31] Although rarely resorted to in modern times, striking the ganglion cyst with a large tome usually is sufficient to rupture the cyst and re-accumulation is uncommon with this treatment.

See also

References

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  7. Lua error in package.lua at line 80: module 'strict' not found.
  8. Lua error in package.lua at line 80: module 'strict' not found.
  9. Arend CF. Ultrasound of the Shoulder. Master Medical Books, 2013. Sample chapter available on acromioclavicular joint ganglion.
  10. Lua error in package.lua at line 80: module 'strict' not found. (includes MRI images)
  11. Lua error in package.lua at line 80: module 'strict' not found.
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  14. 14.0 14.1 Lua error in package.lua at line 80: module 'strict' not found. (original source cites eight additional references for the quoted paragraph)
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  18. http://www.bionity.com/en/encyclopedia/Ganglion_cyst.html
  19. 19.0 19.1 Lua error in package.lua at line 80: module 'strict' not found.
  20. 20.0 20.1 20.2 Lua error in package.lua at line 80: module 'strict' not found.
  21. Bismil MSK, Bismil QMK. The wide awake approach to hand and wrist ganglia: Ten-year experience, technical tips and review of macroscopic pathology and outcomes of 300 cases. OA Case Reports 2013 Nov 15;2(13):129.
  22. Lua error in package.lua at line 80: module 'strict' not found.
  23. Camasta, Craig A., DPM, Excision of the Ganglion Cyst, podiatryinstitute.com, update 1993, 1993 33 pdf, pages 181-5
  24. Lua error in package.lua at line 80: module 'strict' not found.
  25. Lua error in package.lua at line 80: module 'strict' not found.
  26. Dias JJ, Dhukaram V, Kumar P, The natural history of untreated dorsal wrist ganglia and patient reported outcome 6 years after intervention. J Hand Surg Eur Vol. 2007 Oct;32(5) 502-8.
  27. Dias J, Buch K. Palmar wrist ganglion: does intervention improve outcome? A prospective study of the natural history and patient-reported treatment outcomes. J Hand Surg Br. 2003 Apr;28(2) 172-6.
  28. Lua error in package.lua at line 80: module 'strict' not found. (see the entry for aneurysmal bone cyst, which "like pyogenic granuloma and ganglion cyst, a misnomer that has withstood the sands of time and the dint of logic")
  29. Lua error in package.lua at line 80: module 'strict' not found.
  30. See Hippocrates' "On the Articulations" (part 40) at Wikisource
  31. http://www.eatonhand.com/hw/hw013.htm

External links