HAMP

This article is about the protein that is encoded by the HAMP gene. For other uses, see HAMP (disambiguation).

Hepcidin antimicrobial peptide
250px PDB rendering based on 1m4f.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifiers
Symbols	HAMP ; HEPC; HFE2B; LEAP1; PLTR
External IDs	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP Gene
Gene ontology Molecular function • receptor binding • hormone activity • iron channel inhibitor activity Cellular component • extracellular region • extracellular space • cell • apical cortex Biological process • positive regulation of receptor internalization • cellular iron ion homeostasis • immune response • response to iron ion • killing of cells of other organism • negative regulation of ion transmembrane transporter activity • defense response to bacterium • defense response to fungus • multicellular organismal iron ion homeostasis • positive regulation of protein polyubiquitination • negative regulation of ferrous iron export • negative regulation of iron channel activity • negative regulation of intestinal absorption • positive regulation of receptor catabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE HAMP 220491 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57817	n/a
Ensembl	ENSG00000105697	n/a
UniProt	P81172	n/a
RefSeq (mRNA)	NM_021175	n/a
RefSeq (protein)	NP_066998	n/a
Location (UCSC)	Chr 19: 35.28 – 35.29 Mb	n/a
PubMed search	[1]	n/a

Hepcidin is a protein that in humans is encoded by the HAMP gene.

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

See also

• Hepcidin

External links

• GeneReviews/NCBI/NIH/UW entry on Juvenile Hereditary Hemochromatosis

This article incorporates text from the United States National Library of Medicine, which is in the public domain.