Hexacyclonate

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Hexacyclonate
Hexacyclonate.svg
Systematic (IUPAC) name
[1-(hydroxymethyl)cyclohexyl]acetic acid
Identifiers
CAS Number 7491-42-1
PubChem CID: 23444
ChemSpider 21921 YesY
UNII 2K0FP9UB6A YesY
ChEMBL CHEMBL2110826
Chemical data
Formula C9H16O3
Molecular mass 172.222
  • O=C(O)CC1(CO)CCCCC1
  • InChI=1S/C9H16O3/c10-7-9(6-8(11)12)4-2-1-3-5-9/h10H,1-7H2,(H,11,12) YesY
  • Key:WMJPAYUKEVEBCN-UHFFFAOYSA-N YesY
  (verify)

Hexacyclonate (Gevilon) is a stimulant drug. It has been used for the treatment of alcoholism[1] and for increasing motivation in elderly patients,[2] but is now mainly used for the treatment of hyperlipoproteinaemia. [3][4] It is chemically similar to the anticonvulsant gabapentin, with a hydroxyl group replacing the amine.

The latter use may be incorrectly assigned, as "Gevilon" has been used as a trade name for gemfibrozil, a well-known drug for dislypidemia.

References

  1. ↑ Chesrow EJ, Sabatini R, Musci JP, Kaplitze SE, Marquardt GH. Adjunctive treatment of the chronic alcoholic with hexacyclonate sodium. Illinois Medical Journal. 1962 May;121:546-8.
  2. ↑ Morrison BO. Pharmaco-motivation of the geriatric patient: a preliminary report on hexacyclonate. Journal of the Louisiana State Medical Society. 1962 Jan;114:23-6.
  3. ↑ Milewicz A, Plamieniak Z, Bohdanowicz-Pawlak A. Therapeutic effect of gevilon in patients with hyperlipoproteinaemia. Polish Journal of Medicine and Pharmacy. 1992 Apr-Jun;24(2):91-5.
  4. ↑ Gazdikova K, Korecka P, Springer V, Gazdik F. Pharmacoeconomic aspects of patients treated by hemodialysis. Bratislavske Lekarske Listy. 2003;104(10):329-34.


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