Interleukin 30

Interleukin 27
Identifiers
Symbols	IL27 ; IL-27; IL-27A; IL27A; IL27p28; IL30; p28
External IDs	OMIM: 608273 HomoloGene: 17087 GeneCards: IL27 Gene
Gene ontology Molecular function • receptor binding • cytokine activity • interleukin-27 receptor binding Cellular component • extracellular space Biological process • inflammatory response • response to bacterium • regulation of T cell proliferation • positive regulation of interferon-gamma biosynthetic process • innate immune response • regulation of T-helper 1 cell differentiation • regulation of defense response to virus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246778	246779
Ensembl	ENSG00000197272	ENSMUSG00000044701
UniProt	Q8NEV9	Q8K3I6
RefSeq (mRNA)	NM_145659	NM_145636
RefSeq (protein)	NP_663634	NP_663611
Location (UCSC)	Chr 16: 28.5 – 28.51 Mb	Chr 7: 126.59 – 126.59 Mb
PubMed search	[1]	[2]

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6. This gene for this molecule is now officially called IL-27 under HGNC guidelines.