Irazepine

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Irazepine
Irazepine.svg
Systematic (IUPAC) name
7-chloro-5-(2-fluorophenyl)-1-(2-isothiocyanatoethyl)-3H-1,4-benzodiazepin-2-one
Identifiers
CAS Number 71735-92-7 YesY
PubChem CID: 194406
ChemSpider 168688 YesY
Chemical data
Formula C18H13ClFN3OS
Molecular mass 373.83 g/mol
  • C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN=C=S
  • InChI=1S/C18H13ClFN3OS/c19-12-5-6-16-14(9-12)18(13-3-1-2-4-15(13)20)22-10-17(24)23(16)8-7-21-11-25/h1-6,9H,7-8,10H2
  • Key:LTKSVYFAUMFQML-UHFFFAOYSA-N
 NYesY (what is this?)

Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepine, kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.[3]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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