Irwin Rose

Irvin Rose
Irwin Rose, c. 2000
Born	Irwin Allan Rose (1926-07-16)July 16, 1926 Brooklyn, New York, U.S.
Died	Deerfield, Massachusetts, U.S.
Nationality	United States
Fields	Biology
Institutions	Fox Chase Cancer Center University of Pennsylvania University of California, Irvine Yale University
Alma mater	University of Chicago (BS, PhD)
Known for	Ubiquitin-mediated protein degradation
Notable awards	Nobel Prize in Chemistry (2004)
Spouse	Zelda Budenstein
Children	4

Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Education and early life

Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago.

Career and research

Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995. He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry. He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004.

Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.

Awards and honours

Rose was awarded the Nobel prize in 2004.

Personal life

Rose was married to Zelda Budenstein and had four children. He died on June 2, 2015 at Deerfield, Massachusetts.