JWH-098

JWH-098

Systematic (IUPAC) name
4-methoxynaphthalen-1-yl-(1-pentyl-2-methylindol-3-yl)methanone
Clinical data
Legal status	CA: Schedule II UK: Class B
Identifiers
CAS Number	316189-74-9
PubChem	CID: 45272116
ChemSpider	24628229
Chemical data
Formula	C26H27NO2
Molecular mass	385.497 g/mol
SMILES CCCCCn(c1C)c2ccccc2c1C(=O)c(ccc3OC)c4ccccc34
InChI InChI=1S/C26H27NO2/c1-4-5-10-17-27-18(2)25(22-13-8-9-14-23(22)27)26(28)21-15-16-24(29-3)20-12-7-6-11-19(20)21/h6-9,11-16H,4-5,10,17H2,1-3H3 Key:CNTCHEBQQFICNR-UHFFFAOYSA-N
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JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB₁ and CB₂ receptors. While JWH-081 is around 10x selective for CB₁ over CB₂, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB₁ while being six times more potent at CB₂, giving it a slight selectivity for CB₂ overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB₂ affinity, but often at the expense of CB₁ binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.

See also

• JWH-007
• JWH-081