JWH-359

JWH-359

Systematic (IUPAC) name
(6aR,10aR)- 1-methoxy- 6,6,9-trimethyl- 3-[(2R)-1,1,2-trimethylbutyl]- 6a,7,10,10a-tetrahydrobenzo[c]chromene
Identifiers
ChemSpider	35303437
Chemical data
Formula	C24H36O2
Molecular mass	356.540 g/mol
SMILES COc2cc(C(C)(C)C(C)CC)cc3c2C1CC(C)=CCC1C(C)(C)O3
InChI InChI=1S/C24H36O2/c1-9-16(3)23(4,5)17-13-20(25-8)22-18-12-15(2)10-11-19(18)24(6,7)26-21(22)14-17/h10,13-14,16,18-19H,9,11-12H2,1-8H3/t16-,18-,19-/m1/s1 Key:BDJRWUBZMGSKHL-BHIYHBOVSA-N
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JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB₂ receptor agonist, with a K_i of 13.0nM and selectivity of around 220x for CB₂ over CB₁ receptors. It is related to other dibenzopyran CB₂ agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful in mapping the shape of the CB₂ binding site. It was discovered by, and named after, Dr. John W. Huffman.