L-371,257

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L-371,257
File:L-371,257 structure.png
Systematic (IUPAC) name
1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine
Identifiers
CAS Number 162042-44-6 YesY
PubChem CID: 6918320
IUPHAR/BPS 2252
ChemSpider 5293524 N
ChEMBL CHEMBL24781 N
Chemical data
Formula C28H33N3O6
Molecular mass 507.577 g/mol
  • O=C1OCc3ccccc3N1C(CC4)CCN4C(=O)c2ccc(cc2OC)OC5CCN(C(C)=O)CC5
  • InChI=1S/C28H33N3O6/c1-19(32)29-15-11-22(12-16-29)37-23-7-8-24(26(17-23)35-2)27(33)30-13-9-21(10-14-30)31-25-6-4-3-5-20(25)18-36-28(31)34/h3-8,17,21-22H,9-16,18H2,1-2H3 N
  • Key:WDERJSQJYIJOPD-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

L-371,257 is a compound used in scientific research which acts as a selective antagonist of the oxytocin receptor with over 800x selectivity over the related vasopressin receptors.[1] It was one of the first non-peptide oxytocin antagonists developed,[2][3][4][5] and has good oral bioavailability, but poor penetration of the blood–brain barrier, which gives it good peripheral selectivity with few central side effects.[6] Potential applications are likely to be in the treatment of premature labour.[7]

See also

References

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