L-765,314

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L-765,314
L-765,314 structure.png
Systematic (IUPAC) name
benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate
Identifiers
PubChem CID: 6603904
IUPHAR/BPS 506
ChEMBL CHEMBL19476 N
Chemical data
Formula C27H34N6O5
Molecular mass 522.595 g/mol
  • COc3cc2c(cc3OC)nc(nc2N)N(CC1C(=O)NC(C)(C)C)CCN1C(=O)OCc4ccccc4
 NYesY (what is this?)  (verify)

L-765,314 is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B.[1] It has mainly been used to investigate the role of α1B receptors in the regulation of blood pressure.[2][3] The α1B receptor is also thought to have an important role in the brain; however, L-765,314 does not cross the blood–brain barrier.[4]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.

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