LRRTM1
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LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.[1][2] As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).[3][4]
Clinical significance
LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side.[5] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.[5] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[6] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
See also
References
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Further reading
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| Laterality | |||
|---|---|---|---|
| Side | Left | Both | Right |
| General | Ambidexterity | ||
| In cognitive abilities | Geschwind–Galaburda hypothesis | ||
| In brain | |||
| In eyes | Ocular dominance | ||
| In hands | Left-handedness | Cross-dominance | Right-handedness |
| Handedness in boxing | Southpaw stance | Orthodox stance | |
| Handedness in people | |||
| Handedness related to | |||
| Handedness measurement | Edinburgh Handedness Inventory | ||
| Handedness genetics | LRRTM1 | ||
| In heart | Levocardia | Dextrocardia | |
| In major viscera | Situs solitus | Situs ambiguus | Situs inversus |
| In feet | Footedness | ||
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