Tandem pore domain potassium channel

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The two-pore-domain potassium channel (not to be confused with the small family of two-pore channels) a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins .[citation needed] Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

Gene Channel[2] Family Aliases
KCNK1 K2p1.1 TWIK[3][4] TWIK-1
KCNK2 K2p2.1 TREK[3][4] TREK-1
KCNK3 K2p3.1 TASK[3][4] TASK-1
KCNK4 K2p4.1 TREK[3][4] TRAAK[5]
KCNK5 K2p5.1 TASK[3][4] TASK-2[6]
KCNK6 K2p6.1 TWIK[3][4] TWIK-2
KCNK7 K2p7.1 TWIK[3][4]
KCNK9 K2p9.1 TASK[3][4] TASK-3
KCNK10 K2p10.1 TREK[3][4] TREK-2
KCNK12 K2p12.1 THIK THIK-2
KCNK13 K2p13.1 THIK THIK-1
KCNK15 K2p15.1 TASK[3][4] TASK-5
KCNK16 K2p16.1 TALK[3][4] TALK-1
KCNK17 K2p17.1 TALK[3][4] TALK-2, TASK-4
KCNK18 K2p18.1 TRIK, TRESK[3][4][7][8]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links


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