Linda B. Buck
| Linda Buck | |
|---|---|
Linda Buck in 2015, portrait via the Royal Society
|
|
| Born | Linda Brown Buck January 29, 1947 [1] Seattle, Washington, U.S. |
| Nationality | American |
| Fields | Biologist |
| Institutions | Fred Hutchinson Cancer Research Center University of Washington, Seattle Howard Hughes Medical Institute Columbia University Harvard University[2] |
| Alma mater | <templatestyles src="Plainlist/styles.css"/>
|
| Known for | Olfactory receptors |
| Notable awards | <templatestyles src="Plainlist/styles.css"/>
|
| Spouse | Roger Brent |
| Website www |
|
Linda Brown Buck (born January 29, 1947)[1] is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors.[5][6][7][8] She is currently on the faculty of the Fred Hutchinson Cancer Research Center in Seattle.[9]
Contents
Education and early life
Born in Seattle, Washington, Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle and her Ph.D. in immunology in 1980 from the University of Texas Southwestern Medical Center at Dallas.[10]
Career and research
Buck completed postdoctoral research at Columbia University under Axel. In 1991 Buck became an assistant professor of neurobiology at Harvard University where she expanded her knowledge of the nervous system.[11] Her primary research interest is on how pheromones and odors are detected in the nose and interpreted in the brain. She is a Full Member of the Basic Sciences Division at Fred Hutchinson Cancer Research Center, an Affiliate Professor of Physiology and Biophysics at the University of Washington, Seattle and an Investigator of the Howard Hughes Medical Institute.
In their landmark paper published in 1991,[10] Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors. By analyzing rat DNA, they estimated that there were approximately one thousand different genes for olfactory receptors in the mammalian genome. This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction. In their later work, Buck and Axel have shown that each olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated glomerulus of the olfactory bulb.
Awards and honors
Buck was inducted into the National Academy of Sciences in 2004. Buck was elected a Fellow of the American Academy of Arts and Sciences in 2008.[12] She also sits on the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize. On May 28, 2015, she was awarded an honorary doctorate by Harvard University. Buck was elected a Foreign Member of the Royal Society (ForMemRS) in 2015.[4]
Personal life
Buck is married to biologist Roger Brent.[10]
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references> tag; parameter "group" is allowed only.
<references />, or <references group="..." /> |
Wikimedia Commons has media related to Linda B. Buck. |
Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found. (subscription required)
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Buck L., Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991;65:175-87. doi:10.1016/0092-8674(91)90418-X PMID 1840504.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 10.0 10.1 10.2 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- Pages with reference errors
- Commons category link is defined as the pagename
- 1947 births
- Living people
- American neuroscientists
- Columbia University alumni
- Nobel laureates in Physiology or Medicine
- American Nobel laureates
- University of Washington alumni
- University of Washington faculty
- Harvard University staff
- Howard Hughes Medical Investigators
- American women scientists
- Women neuroscientists
- Fellows of the American Academy of Arts and Sciences
- Fellows of the American Association for the Advancement of Science
- Members of the United States National Academy of Sciences
- People from Seattle, Washington
- University of Texas Southwestern Medical Center alumni
- Women Nobel laureates
- 20th-century women scientists
- Pages containing links to subscription-only content
