Lysyl hydroxylase
From Infogalactic: the planetary knowledge core
| procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | |
|---|---|
| Identifiers | |
| Symbol | PLOD1 |
| Alt. symbols | LLH, PLOD |
| Entrez | 5351 |
| HUGO | 9081 |
| OMIM | 153454 |
| RefSeq | NM_000302 |
| UniProt | Q02809 |
| Other data | |
| EC number | 1.14.11.4 |
| Locus | Chr. 1 p36.3-36.2 |
| procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | |
|---|---|
| Identifiers | |
| Symbol | PLOD2 |
| Entrez | 5352 |
| HUGO | 9082 |
| OMIM | 601865 |
| RefSeq | NM_000935 |
| UniProt | O00469 |
| Other data | |
| Locus | Chr. 3 q24 |
Lysyl hydroxylase (or procollagen-lysine 5-dioxygenase) is an oxygenase enzyme that catalyzes the hydroxylation of lysine to hydroxylysine.[1][2] This reaction is necessary to the formation and stabilization of collagen. It takes place following protein synthesis (as a post-translational modification). The protein is a membrane-bound homodimeric enzyme that is localized to the cisternae (lumen) of the rough endoplasmic reticulum.
It requires iron and vitamin C as cofactors.
Pathology
A deficiency in its cofactor, Vitamin C, is associated with Scurvy.
References
External links
- Lysyl Hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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