Marburg's variant multiple sclerosis
Marburg's variant of multiple sclerosis, also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are neuromyelitis optica (NMO), Balo concentric sclerosis, and Schilder's disease.[1] The graver course is one form of malignant multiple sclerosis, with patients reaching a significant level of disability in less than five years from their first symptoms, often in a matter of months.[2]
It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan.[3] If Marburg disease occurs in the form of a single large lesion, it can be radiologically indistinguishable from a brain tumor or abscess. In such cases, craniotomy and biopsy are needed to exclude other pathologies.[4] It is usually lethal, but it has been found to be responsive to Mitoxantrone[5] and Alemtuzumab,[6] and it has also been responsive to autologous stem cell transplantation.[7] Recent evidence shows that Marburg's presents a heterogeneous response to medication, as does standard MS.[8]
Sometimes Marburg MS is considered a synonym for tumefactive MS.[9] but not for all authors[10]
Prognosis
Marburg variant of MS is an acute fulminant demyelinating process which in most cases progresses inexorably to death within 1–2 years.[11] However, threre are some reports of Marburg MS reaching stability by three years.[12]
References
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- ↑ Ayumi Ludwig et al, Marburg’s Variant of Multiple Sclerosis with Extensive Brain Lesions: An Autopsy Case Report. Int J Neurol Neurother 2015, 2:2 [1]
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External links
- Marburg's Variant (Mult-sclerosis Encyclopedia)
