NKX6-1

NK6 homeobox 1
Identifiers
Symbols	NKX6-1 ; NKX6.1; NKX6A
External IDs	OMIM: 602563 MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding Cellular component • nucleoplasm • extracellular exosome Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • smoothened signaling pathway • organ morphogenesis • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • regulation of axon extension • pancreas development • endocrine pancreas development • positive regulation of insulin secretion • response to nicotine • response to drug • type B pancreatic cell proliferation • positive regulation of neuron differentiation • negative regulation of glial cell differentiation • positive regulation of glial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • oligodendrocyte differentiation • positive regulation of sequence-specific DNA binding transcription factor activity • detection of glucose • cellular response to cytokine stimulus • cellular response to peptide hormone stimulus • type B pancreatic cell maturation • positive regulation of type B pancreatic cell development • regulation of neuron migration Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4825	18096
Ensembl	ENSG00000163623	ENSMUSG00000035187
UniProt	P78426	Q99MA9
RefSeq (mRNA)	NM_006168	NM_144955
RefSeq (protein)	NP_006159	NP_659204
Location (UCSC)	Chr 4: 84.49 – 84.5 Mb	Chr 5: 101.66 – 101.66 Mb
PubMed search	[1]	[2]

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.