GRIN2B
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B) is a protein that in humans is encoded by the GRIN2B gene.[1]
Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.[2]
NR2B has been associated with age and visual experience dependent plasticity in the neocortex of rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals. This is thought to contribute to experience-dependent refinement of developing cortical circuits.[3]
Ligands
- Besonprodil
- CERC-301 selective NR2B receptor antagonist
- Eliprodil
- Evt 101, a selective NR2B receptor antagonist, was tested as a potentially fast acting antidepressant.[4]
In 2011 it was voluntarily withdrawn from a Phase II clinical study in treatment-resistant depression due to an unsatisfactory toxicity profile.[5]
- Ro-25-6981 (also known as MI-4) - selective NR2B receptor antagonist
- Traxoprodil selective NR2B receptor antagonist
Interactions
GRIN2B has been shown to interact with:
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See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
