Nifene

Nifene (¹⁸F)

Systematic (IUPAC) name
3-[(2S)-2,5-Dihydro-1H-pyrrol-2-ylmethoxy]-2-18F-fluoropyridine
Clinical data
Pregnancy category	N/A
Legal status	Research compound
Identifiers
ATC code	none
PubChem	CID: 6917075
ChemSpider	5292349
Chemical data
Formula	C10H11FN2O
Molecular mass	193.208078 g/mol
SMILES C1C=C[C@H](N1)COC2=C(N=CC=C2)[18F]
InChI InChI=1S/C10H11FN2O/c11-10-9(4-2-6-13-10)14-7-8-3-1-5-12-8/h1-4,6,8,12H,5,7H2/t8-/m0/s1/i11-1 Key:GHHQHFNDKOQCRS-IZFLLFDKSA-N

Nifene is a high affinity, selective nicotinic α4β2 receptor agonist used in medical research for nicotinic acetylcholine receptors, usually in the form of nifene (¹⁸F) as a positron emission tomography (PET) radiotracer.

Nifene has been used to assess the efficacy of acetylcholinesterase inhibitors in animal models, because the neurotransmitter acetylcholine competes with the binding of nifene at the nicotinic receptor site. Learning and behavior studies in animal models using nifene have suggested a potential role of the nicotinic receptors located in distinct white matter tracts. Nifene studies in animal models of lung cancer have suggested an upregulation of the nicotinic receptor in the lung tumors. Novel PET and SPECT imaging agents as potential receptor antagonists have been developed based on the structure of nifene; niodene for SPECT, nifrolene for PET and niofene for PET/SPECT. These new derivatives take advantage of the unique in vivo imaging properties of nifene.

External links

• ChemSpider