O-774

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O-774
O-774 structure.png
Systematic (IUPAC) name
7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-7-methyloctanenitrile
Identifiers
PubChem CID: 10833730
ChemSpider 9009030
Chemical data
Formula C25H35NO2
Molecular mass 381.550 g/mol
  • N#CCCCCCC(c2cc1OC([C@@H]3C/C=C(\C[C@H]3c1c(O)c2)C)(C)C)(C)C
  • InChI=1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1
  • Key:RVTLXKSJDYALPU-WOJBJXKFSA-N
 NYesY (what is this?)

O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.[1][2]

See also

References

  1. ↑ Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. PMID 9784115
  2. ↑ The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp 6-9. Edited by Patricia H Reggio. Humana Press 2009. ISBN 978-1-58829-712-9


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