Org 37,684

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Org 37,684
Org37684 structure.png
Systematic (IUPAC) name
(3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS Number 213007-95-5
PubChem CID: 9794656
IUPHAR/BPS 171
Chemical data
Formula C14H19NO2
Molecular mass 233.305 g/mol
  • COc1ccc2CCCc2c1OC3CNCC3
  (verify)

Org 37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004;370:114-123. doi:10.1007/s00210-004-0951-4 PMID 15322733
  3. ↑ Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in Neuropsychopharmacology and Biological Psychiatry. 2002 Apr;26(3):441-9. PMID 11999893



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