Oroxylin A

Oroxylin A
	Skeletal formula
	Ball-and-stick model of oroxylin A
Names
	IUPAC name 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
	Other names Baicalein 6-methyl ether
Identifiers
CAS Number	480-11-5
ChEBI	CHEBI:61668
ChemSpider	4478428
Jmol 3D model	Interactive image
PubChem	5320315
	InChI InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5- 3-2-4-6-9/h2-8,18-19H,1H3 Key: LKOJGSWUMISDOF-UHFFFAOYSA-N ;
	SMILES COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=CC=C3)O ;
Properties
Chemical formula	C16H12O5
Molar mass	284.26 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plant Scutellaria baicalensis^[1] and the Oroxylum indicum tree.^[2] It has demonstrated activity as a dopamine reuptake inhibitor,^[3] and is also a negative allosteric modulator of the benzodiazepine site of the GABA_A receptor.^[3]^[4]^[5] Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus.^[6]

References

↑ Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. Hua-Bin Li and Feng Chen, Journal of Chromatography A, 13 May 2005, Volume 1074, Issues 1–2, pages 107–110, doi:10.1016/j.chroma.2005.03.088
↑ The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum, vent R. C. Shah, C. R. Mehta and T. S. Wheeler
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