Patrick Soon-Shiong

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Patrick Soon-Shiong
Dr Patrick Soon-Shiong (14212355607).jpg
Soon-Shiong at the 2014 NHS Confederation conference.
Native name Soon-Shiong黄馨祥
Born July 29, 1952 (1952-07-29) (age 71)
Port Elizabeth, South Africa
Nationality American
Alma mater University of Witwatersrand
University of British Columbia
University of California at Los Angeles Medicine & Surgery
Occupation
  • Surgeon (former)
  • medical researcher (former)
  • entrepreneur and philanthropist
Known for
  • inventing Abraxane
  • developing pancreatic islet cell transplant techniques
Net worth US$12.7 billion (September 2015)[1]
Spouse(s) Michele B. Chan[2]:138[3]
Children 2[4]

Dr. Patrick Soon-Shiong (Chinese: 陈颂雄.Soon-Shiong黄馨祥; pinyin: Huáng Xīnxiáng, Mandarin pronunciation: [xu̯ɑ̌ŋ ɕín ɕi̯ɑ̌ŋ]; born July 29, 1952) is a South African-born American surgeon, medical researcher, businessman, philanthropist, and professor at University of California at Los Angeles. He is currently chairman of the Chan Soon-Shiong Family Foundation and chairman and CEO of the Chan Soon-Shiong Institute for Advanced Health, National LambdaRail, the Healthcare Transformation Institute and NantWorks, LLC.[5] In October 2010, he bought Earvin "Magic" Johnson's minority ownership stake in the Los Angeles Lakers.[6] As of January 2016, Soon-Shiong was estimated by Forbes as having a net worth of US$12.5 billion, ranking him #37 among US billionaires, the wealthiest American in the healthcare industry, and the wealthiest person in Los Angeles.[4][7]

Early life and ancestry

Soon-Shiong was born in Port Elizabeth, South Africa to Chinese immigrant parents who fled from China during the Japanese occupation in World War II.[2][8] His parents are from Taishan in Guangdong, China,[8] and he is a Hakka.[2]

Education

He graduated from high school at age 16 and graduated 4th out of 189 in his class when received his MBBCh medical degree at age 23 from the University of Witwatersrand, where he studied on a scholarship.[9] Soon-Shiong completed his medical internship at Johannesburg’s General Hospital. He then studied at the University of British Columbia, where he earned a MSc degree and received research awards from the American College of Surgeons, the Royal College of Physicians and Surgeons of Canada, and the American Association of Academic Surgery, making him the first resident of the university to do so.[10] He initiated his surgical training at University of California, Los Angeles (UCLA), after moving to the United States, becoming a board-certified surgeon. Dr Soon-Shiong is a Fellow of the Royal College of Surgeons (Canada) and a Fellow of the American College of Surgeons.[10][11][12]

Medical and academic career

Soon-Shiong joined UCLA Medical School in 1983,[12] and served on the faculty until 1991,[13] during which time he was a practicing transplant surgeon.[2]:138 Between 1984 and 1987, he served as an associate investigator at the Center for Ulcer Research and Education.[13] He performed the world's first full pancreas transplant in 1987;[11][not in citation given] developed an experimental treatment for Type 1 diabetes known as encapsulated human islet transplant; and performed the world's first encapsulated human-to-human and pig-to-human islet transplants in 1993. After a period as a pharmaceutical company entrepreneur, he returned to UCLA in 2009, serving as a professor of microbiology, immunology, molecular genetics and bioengineering.

Entrepreneurial activities

In 1991, Soon-Shiong left UCLA to start a diabetes and cancer biotechnology firm. This led to the founding in 1997 of APP Pharmaceuticals (APP), which he sold to Fresenius SE for US$3.7 billion in July 2008.[14] At the time of the sale, Soon-Shiong held 80% of outstanding APP stock, sale of which was part of the transaction.[14] Soon-Shiong later founded Abraxis BioScience, maker of his drug Abraxane, a company he sold to Celgene in 2010 in cash-and-stock deal, valued at over US$3 billion.[15]

Soon-Shiong founded NantHealth in 2007 to provide fiber-optic, cloud-based data infrastructure to share healthcare information.[16] Soon-Shiong went on to found NantWorks in September 2011, which mission was "to converge ultra-low power semiconductor technology, supercomputing, high performance, secure advanced networks and augmented intelligence to transform how we work, play, and live."[17][18] In October, 2012, Soon-Shiong announced that NantHealth’s supercomputer-based system and network were able to analyze the genetic data from a tumor sample in 47 seconds and transfer the data in 18 seconds. The goal of developing this infrastructure and digital technologies was to share genomic information among sequencing centers, medical research hubs and hospitals, and to advance cancer research and big science endeavors such as The Cancer Genome Atlas.[19] In January 2013, he founded another biotech company, NantOmics, to develop cancer drugs based on protein kinase inhibitors. NantOmics and its sister company, NantHealth, were subsidiaries of NantWorks. Soon-Shiong stated that NantWorks’ vision for the future of cancer treatment was a convergence of multiple technologies that included diagnostics, supercomputing, network modeling of sharing data on tumor genes and personalized concoction of cancer drugs in combination for multi-targeted attacks. The goal was to manage cancer and achieve a sustained disease-free state.[20]

In 2010, with Arizona State University and the University of Arizona, Soon-Shiong founded the Healthcare Transformation Institute (HTI), which he dubs a "do-tank".[21] HTI's mission is to promote a paradigm shift in health care in the United States by better integrating the three now separate domains of medical science, health delivery, and healthcare finance.[5][22]

In July 2015, Soon-Shiong initiated an IPO for NantKwest (formerly ConkWest) that represented the highest value biotech IPO in history, at a market value of $2.6 billion.[23]

Executive activities

Soon-Shiong heads the CSS Institute for Advanced Health, founded in 2011 with a mission to provide high-speed computing capabilities for human genotyping to target specific cancer treatments, as well as technologies for the better management of chronic disease. Through the CSS Institute, Soon-Shiong is working to create a national health information network for the secure sharing of biomedical information. He is supporting the development of various wireless technologies for the better management of chronic disease.[24]

Soon-Shiong is on several boards. These include the Board of Directors of the Mendez National Institute of Transplantation,[25] and the board of directors for the Technology Council for the Center for Cancer Nanotechnology Excellence at Northwestern University.[26] He leads other organizations concurrently. He is Chairman of the National Coalition for Health Integration,[27] and is the Executive Director of the UCLA Wireless Health Institute.[28]

Awards

Soon-Shiong’s research has been recognized by national and international awards such as the Association for Academic Surgery Award for Research, the American College of Surgeons Schering Scholar, the Royal College Physicians and Surgeons Research Award, the Peter Kiewit Distinguished Membership in Medicine Award, and the International J.W. Hyatt Award for Service to Mankind. Soon-Shiong received the 2006 Gilda Club Award for the advancement of cancer medicine and is a recipient of a 2007 Ellis Island Medal of Honor as well as the St. Mary Medical Center Life Achievement Award in 2007 and the St. John’s Health Center Caritas Award in 2007. In 2008, he received the Medical Visionary Award from the Pancreatic Cancer Action Network for his work in pancreatic cancer & the Los Angeles County Economic Development Council (LAEDC) Eddy Award in November 2009. The Los Angeles Business Journal recognized him as their 2010 Business Person of the Year, and the National Library of Medicine awarded Soon-Shiong the Distinguished Medical Science Award. The University of Arizona awarded him an honorary doctorate in December 2010, and Visiting Professor of the Imperial College of London in 2011.[29]

Legacy

In 2010, in partnership with the LA Business Journal, Soon-Shiong founded the “Patrick Soon-Shiong Innovation Awards”; the first winners of these annual awards were six companies from the media, entertainment, engineering and aerospace sectors.[30] The third annual Patrick Soon-Shiong Innovation Awards will take place in the fall of 2012.

In addition to his methods development in transplant surgery, Soon-Shiong invented the nation’s first FDA-approved protein nanoparticle delivery technology for the treatment of metastatic breast cancer, doubling the response rate in patients. The cancer drug he invented, Abraxane, has been approved for use in over 40 countries. He is listed as a co-inventor on over 114 issued patents and has published more than 100 scientific papers. Among those 114 patents is one for the distribution of natural light to underground facilities, like that of his home gymnasium.[2]:140[lower-alpha 1]

He has developed and sold two multibillion-dollar pharmaceutical companies, American Pharma Partners (APP) and Abraxis BioScience (ABII). APP was responsible for the only safe supply of Heparin in the United States in 2008, when supplies from other sources were found to be tainted.[31]

Philanthropy

Soon-Shiong and his wife, Michele B. Chan, fund several health-related projects through the Chan Soon-Shiong Family Foundation. In 2007 they pledged US $1billion to support healthcare transformation and a national health information highway. The Foundation has given a total of $135 million to the Saint John's Health Center in Santa Monica, California.

It gave a guarantee of $100 million that enabled the replacement of closed Martin Luther King Jr./Drew Medical Center with the new Martin Luther King, Jr. Community Hospital in Willowbrook. Its Summer 2015 opening restored healthcare access to the largely underserved residents of South Los Angeles.[32]

In 2010, Soon-Shiong and Chan were asked to and did join Bill Gates and Warren Buffett in taking The Giving Pledge,[2]:138 by which some of the wealthiest Americans have pledged to give the majority of their wealth to charitable causes. They will donate half their wealth.[33][34]

In 2011 Soon-Shiong and Chan endowed a new Chair at the USC Viterbi School of Engineering, to support research at intersection of engineering and medicine, specifically computer science, mobile vision, and robotics.[35]

Notes

  1. ↑ As of Nov 2015, unable to specify patent at USPTO.

References

  1. ↑ http://www.forbes.com/profile/patrick-soon-shiong/
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Biography for Michele B. Chan at the Internet Movie Database
  4. ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ 8.0 8.1 Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ 10.0 10.1 Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ 11.0 11.1 Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ 12.0 12.1 Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ 13.0 13.1 Lua error in package.lua at line 80: module 'strict' not found.
  14. ↑ 14.0 14.1 Lua error in package.lua at line 80: module 'strict' not found.
  15. ↑ Lua error in package.lua at line 80: module 'strict' not found.(subscription required)
  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  19. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  23. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  24. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  25. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  26. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  27. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  28. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  29. ↑ 'Visionary healthcare entrepreneur and philanthropist, Dr. Patrick Soon-Shiong, to speak at UCLA Engineering commencement' in "UCLA Engineering", 2011 [1]
  30. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  31. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  32. ↑ 'Pharmaceutical executive donates $100 million to St. John's Health Center' in "Los Angeles Times", October 2, 2009 [2]
  33. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  34. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  35. ↑ Soon-Shiong Gives Multi-Million Dollar Gift to USC Engineering School', in Beverly Hills Courier, September 29, 2011 [3]
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