Philippa Marrack

Philippa "Pippa" Marrack
Born	(1945-06-28) 28 June 1945 Ewell, England
Institutions	National Jewish Health
Alma mater	Cambridge University University of California, San Diego
Doctoral advisor	Alan Munro
Known for	T cells, autoimmune disease
Notable awards	Louisa Gross Horwitz Prize (1995) Dickson Prize (1996)
Spouse	John W. Kappler

Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with her husband, John W. Kappler.

Biography

Marrack was born in Ewell, England on 28 June 1945. She completed both undergraduate and Ph.D. work at New Hall, Cambridge. To earn her Ph.D, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

Significant papers

• J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
• P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
• J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
• J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).

Awards

• 1986 - Appointed Investigator, Howard Hughes Medical Institute
• 1987 - Fellow (elected), Royal Society
• 1989 - Elected member, National Academy of Sciences
• 1990 - Royal Society Wellcome Foundation Prize
• 1993 - Cancer Research Institute William B. Coley Award
• 1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
• 1994 - Louisa Gross Horwitz Prize (Columbia University)
• 2003 - Lifetime Achievement Award, American Association of Immunologists
• 2004 - L'Oreal UNESCO Women in Science Award
• 2005 - Pearl Meister Greengard Prize
• Rabbi Shai Shackner Prize (University of Jerusalem)
• 2015 - Wolf Prize in Medicine
• 2015 - Inducted into the National Women's Hall of Fame

Further reading

• HHMI Profile of work
• "Becoming a Scientist", Philippa Marrack, HHMI
• "Philippa Marrack Targets T Cells and Autoimmune Disease", ScienceWatch
• Christine Bahls, "Philippa Marrack", 'The Scientist v.18, n.6, p. 13 (2004).
• "Profile: Philippa Marrack", Nature Medicine, v.10, n.12.

External links

• Kappler/Marrack Lab