Phosphoramidon
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Skeletal formula of phosphoramidon | |
Space-filling model of the phosphoramidon molecule | |
Names | |
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IUPAC name
(2S)-2-[[(2S)-2-[[hydroxy-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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Other names
N-[N-[[(6-deoxy-α-L-mannoopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan
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Identifiers | |
36357-77-4 | |
ChEBI | CHEBI:45353 |
ChEMBL | ChEMBL479579 |
ChemSpider | 392848 |
EC Number | 252-996-3 |
Jmol 3D model | Interactive image |
KEGG | C00563 |
PubChem | 445114 |
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Properties | |
C23H34N3O10P | |
Molar mass | 543.51 g·mol−1 |
Appearance | White to slightly yellow solid |
Soluble as sodium salt[1] | |
Solubility in DMSO and methanol | Soluble as sodium salt[1] |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
Phosphoramidon is a chemical compound derived from cultures of Streptomyces tanashiensis. It is an inhibitor of the enzyme thermolysin,[2] a membrane metallo-endopeptidase inhibitor,[3] and an endothelin converting enzyme inhibitor.[3] Chemically, talopeptin differs from its closely related peptidase inhibitor talopeptin by a single stereocenter.
Because of its enzyme inhibitory properties, phosphoramidon is widely used as a biochemical tool.
References
- ↑ 1.0 1.1 Phosphoramidon, Enzo Life Sciences
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 3.0 3.1 Phosphoramidon at PubChem
External links
- The MEROPS online database for peptidases and their inhibitors: Phosphoramidon