Pituitary-specific positive transcription factor 1

POU class 1 homeobox 1
PDB rendering based on 1au7.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1au7
Identifiers
Symbols	POU1F1 ; CPHD1; GHF-1; PIT1; POU1F1a; Pit-1
External IDs	OMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription coactivator activity • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription corepressor activity Cellular component • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • cell fate specification • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • negative regulation of cell proliferation • determination of adult lifespan • B cell differentiation • positive regulation of inositol trisphosphate biosynthetic process • positive regulation of multicellular organism growth • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • nuclear transport • somatotropin secreting cell development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5449	18736
Ensembl	ENSG00000064835	ENSMUSG00000004842
UniProt	P28069	Q00286
RefSeq (mRNA)	NM_000306	NM_008849
RefSeq (protein)	NP_000297	NP_032875
Location (UCSC)	Chr 3: 87.26 – 87.28 Mb	Chr 16: 65.52 – 65.54 Mb
PubMed search	[1]	[2]

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.

Function

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and PITX1.

External links

• PIT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Transcription Factor Pit-1 at the US National Library of Medicine Medical Subject Headings (MeSH)