Pruvanserin

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Pruvanserin
Pruvanserin.png
Systematic (IUPAC) name
7-({4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}carbonyl)-1H-indole-3-carbonitrile
Clinical data
Legal status
  • Uncontrolled
Routes of
administration		 Oral
Identifiers
CAS Number 443144-26-1
443144-27-2 (hydrochloride)
ATC code none
PubChem CID: 6433122
ChemSpider 4938310
UNII UL09X1D9EM YesY
ChEMBL CHEMBL1215661
Chemical data
Formula C22H21FN4O
Molecular mass 376.43 g/mol
  • N#Cc2c1cccc(c1nc2)C(=O)N4CCN(CCc3ccc(F)cc3)CC4

Pruvanserin (EMD-281,014, LY-2,422,347) is a selective 5-HT2A receptor antagonist which was under development by Eli Lilly and Company for the treatment of insomnia.[1][2] It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company's development pipeline.[3][4] In addition to its sleep-improving properties,[5][6] pruvanserin has also been shown to have antidepressant, anxiolytic, and working memory-enhancing effects in animal studies.[7][8][9]

See also

References

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