RTI-353

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RTI-353
RTI-353 structure.png
Systematic (IUPAC) name
methyl (1R,2S,3S,5S)-3-(4-ethyl-3-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Identifiers
PubChem CID: 9801045
Chemical data
Formula C17H22INO2
Molecular mass 399.266 g/mol
  • CCC1=C(C=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC)N3)I
  (verify)

RTI-353 is a phenyltropane derived drug which acts as an SSRI.[1][2] Tamagnan et al. also made some phenyltropanes with high activity and selectivity for the SERT (pM affinity).

References

  1. Navarro HA, Xu H, Zhong D, Blough BE, Ross WP, Kuhar MJ, Carroll FI. [(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter. Synapse. 2001 Sep 1;41(3):241-7. PMID 11418937
  2. [1]


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