Rosonabant

Rosonabant
Systematic (IUPAC) name
	(±)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
Identifiers
CAS Number	861151-12-4
ATC code	None
PubChem	CID: 11316914
ChemSpider	9491881
Chemical data
Formula	C21H21Cl3N4O
Molecular mass	451.777 g/mol
	SMILES O=C(NN1CCCCC1)\C4=N\N(c2ccc(Cl)cc2Cl)C(c3ccc(Cl)cc3)C4 ;
	InChI InChI=1S/C21H21Cl3N4O/c22-15-6-4-14(5-7-15)20-13-18(21(29)26-27-10-2-1-3-11-27)25-28(20)19-9-8-16(23)12-17(19)24/h4-9,12,20H,1-3,10-11,13H2,(H,26,29) ; Key:WMMMJGKFKKBRQR-UHFFFAOYSA-N ;

Rosonabant (INN; E-6776) is a drug acting as a CB₁ receptor antagonist/inverse agonist that was under investigation by Esteve as an appetite suppressant for the treatment of obesity.^[1]^[2] Development of the drug for clinical use was apparently halted shortly after the related CB₁ antagonist rimonabant was discontinued, likely due to the reports of severe psychiatric adverse effects such as anxiety, depression, and suicidal ideation associated with it and with similarly-acting agents.^[3]^[4]

References

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