Ruzicka large-ring synthesis
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The Ruzicka large-ring synthesis or Ruzicka reaction or Ruzicka cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone at high temperature and a suitable catalyst such as thorium oxide. The reaction is named after Lavoslav Ružička, who invented it in 1926.[1]
The reaction has been applied in the synthesis of Exaltone, a synthetic Muscone.
References
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