S-17092

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S-17092
S-17092.svg
Systematic (IUPAC) name
[(2S,3aS,7aS)-1([(R,R)-2-phenylcyclopropyl]- carbonyl)-2-([thiazolidin-3-yl]carbonyl)octahydro-1H-indole
Clinical data
Legal status
  • Investigational New Medicine
Identifiers
PubChem CID: 9977327
ChemSpider 8152919
Chemical data
Formula C23H29FN2O2
Molecular mass 384.486 g/mol
  • O=C(N1CCCC1)[C@H]4N(C(=O)[C@H]3[C@H](c2ccc(F)cc2)C3)[C@H]5CCCC[C@H]5C4
  • InChI=1S/C23H29FN2O2/c24-17-9-7-15(8-10-17)18-14-19(18)22(27)26-20-6-2-1-5-16(20)13-21(26)23(28)25-11-3-4-12-25/h7-10,16,18-21H,1-6,11-14H2/t16-,18-,19+,20-,21-/m0/s1
  • Key:JNUXCIMICQKTPX-RQUKQETFSA-N
  (verify)

S-17092 is a drug which acts as a selective inhibitor of the enzyme prolyl endopeptidase.[1] This enzyme is involved in the metabolic breakdown of a number of neuropeptide neurotransmitters in the brain,[2][3] and so inhibiting the action of the enzyme increases the activity of these neuropeptides. This produces nootropic effects which make S-17092 a promising and novel treatment for neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease.[4][5]

See also

References

  1. ↑ Barelli H, Petit A, Hirsch E, Wilk S, De Nanteuil G, Morain P, Checler F. S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase. Biochemical and Biophysical Research and Communications. 1999 Apr 21;257(3):657-61. PMID 10208839
  2. ↑ Bellemère G, Morain P, Vaudry H, Jégou S. Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. Journal of Neurochemistry. 2003 Mar;84(5):919-29. doi:10.1046/j.1471-4159.2003.01536.x PMID 12603817
  3. ↑ Bellemère G, Vaudry H, Morain P, Jégou S. Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain. Journal of Neuroendocrinology. 2005 May;17(5):306-13. PMID 15869566
  4. ↑ Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, Boyer PA. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Reviews. 2002 Spring;8(1):31-52. PMID 12070525
  5. ↑ Morain P, Boeijinga PH, Demazières A, De Nanteuil G, Luthringer R. Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers. Neuropsychobiology. 2007;55(3-4):176-83. PMID 17700042



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