SCH-58261

SCH-58261

Systematic (IUPAC) name
5-Amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine
Clinical data
Legal status	Uncontrolled
Identifiers
CAS Number	160098-96-4 N
ATC code	none
PubChem	CID: 176408
IUPHAR/BPS	403
ChemSpider	153647 Y
ChEMBL	CHEMBL17127 Y
Chemical data
Formula	C18H15N7O
Molecular mass	345.357 g/mol
SMILES c1ccccc1CCN1N=CC2=C1N=C(N)N3C2=NC(C4=CC=CO4)=N3
InChI InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22) Y Key:UTLPKQYUXOEJIL-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A_2A, with more than 50x selectivity for A_2A over other adenosine receptors. It has been used to investigate the mechanism of action of caffeine, which is a mixed A₁ / A_2A antagonist, and has shown that the A_2A receptor is primarily responsible for the stimulant effects of caffeine, but blockade of both A₁ and A_2A receptors is required to accurately replicate caffeine's effects in animals. SCH-58261 has also shown antidepressant and neuroprotective effects in a variety of animal models, and has been investigated as a possible treatment for Parkinson's disease.

See also

• CGS-15943
• Istradefylline (KW-6002)