Sodium salicylate
Names | |
---|---|
IUPAC name
Sodium salicylate
|
|
Other names
Salsonin, Monosodium salicylate, Sodium o-hydroxybenzoate, Sodium 2-hydroxybenzoate, Salicylic acid sodium salt, Monosodium 2-hydroxybenzoate, Diuratin
|
|
Identifiers | |
54-21-7 | |
ChEMBL | ChEMBL447868 |
ChemSpider | 5689 |
DrugBank | DB01398 |
EC Number | 200-198-0 |
Jmol 3D model | Interactive image |
KEGG | D00566 |
PubChem | 16760658 |
RTECS number | VO5075000 |
UNII | WIQ1H85SYP |
|
|
|
|
Properties | |
C7H5NaO3 | |
Molar mass | 160.10 g·mol−1 |
Appearance | white crystals |
Melting point | 200 °C (392 °F; 473 K) |
25.08 g/100 mL (-1.5 °C) 107.9 g/100 mL (15 °C) 124.6 g/100 mL (25 °C) 141.8 g/100 mL (78.5 °C) 179 g/100 g (114 °C)[1] |
|
Solubility | soluble in glycerol, 1,4-Dioxane, alcohol[1] |
Solubility in methanol | 26.28 g/100 g (15 °C) 34.73 g/100 g (67.2 °C)[1] |
Pharmacology | |
ATC code | N02 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|
verify (what is ?) | |
Infobox references | |
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.[2]
Contents
Properties
Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.[citation needed]
Uses
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [3][4][5] and also necrosis.[6] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.[7]
References
- ↑ 1.0 1.1 1.2 http://chemister.ru/Database/properties-en.php?dbid=1&id=2993
- ↑ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
Wikimedia Commons has media related to Salicylates. |
Wikimedia Commons has media related to Salicylate salts. |