Sulfotransferase

The structure and bonding of the sulfate ion

Sulfotransferases EC 2.8.2.- are transferase enzymes that catalyze the transfer of a sulfo group (not a sulfate group) from a donor molecule to an acceptor alcohol or amine. The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R-OSO₃⁻), whereas an amine leads to a sulfo-amine (R-NH-SO₃⁻). Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.

Examples

The following are examples of sulfotransferases:

• carbohydrate sulfotransferase: CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, CHST14
• galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
• heparan sulfate 2-O-sulfotransferase: HS2ST1,
• heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3A2, HS3ST3B1, HS3ST3B2, HS3ST4, HS3ST5, HS3ST6
• heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3
• N-deacetylase/N-sulfotransferase: NDST1, NDST2, NDST3, NDST4
• tyrosylprotein sulfotransferase: TPST1, TPST2
• uronyl-2-sulfotransferase
• Estrone sulfotransferase
• Chondroitin 4-sulfotransferase
• other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1

See also

• List of EC numbers_(EC_2)#EC_2.8.2: Sulfotransferases
• Wikipedia:MeSH_D08#MeSH_D08.811.913.817_---_sulfur_group_transferases_.28EC_2.8.29

External links

• Sulfotransferases at the US National Library of Medicine Medical Subject Headings (MeSH)